익숙한 운동과 새로운 운동이 뇌내 출혈 흰쥐의 운동기능에 미치는 효과 비교

• 영문명: Comparison of the Effects of Familiar Exercise and Novel Exercise on the Motor Function in Rat of lntracerebral Hemorrhage
• 발행기관: 한국전문물리치료학회
• 저자명: 장상훈(Sang-hun Jang) 황경옥(Kyoung-ok Hwang) 김진상(Jin-sang Kim)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제19권 제3호, 72~80쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2012.09.30

영문 초록

The purpose of the present study was to investigate the effects of familiar exercise and novel exercise on motor function after intracerebral hemorrhage (ICH) in rats. The rats were subjected to a unilateral striatal ICH via collagenase infusion. The rats were randomly divided into the following three groups: the CON (control group; rested one week post-ICH), the FE (familiar exercise group; familiar exercise was performed two weeks after one-week post-ICH period) , and NE (novel exercise group; novel exercise was performed two weeks after one-week post-ICH period.) We measured neurological behavior using a ladder rung walking test and a beam walking test; we measured the level of nerve growth factor (NGF) using immunohistochemistry and western blot analysis. We performed a one-way ANOVA test to analyze the scores obtained from the neurological behavior tests and the differences of NGF protein levels among the three groups. In the present study, the FE group and the NE group showed significant improvement during the neurological behavior tests and in their expression of NGF protein level, as compared to the CON group. Especially, NE group more increase than FE group in neurological behavior tests, the expression of NGF on motor cortex. In conclusion, these results suggest that, after ICB, familiar exercise and novel exercise enhance motor function and, novel exercise is more effective than familiar exercise.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

Intracerebral hemorrhage Motor function Nerve growth factor Novel exercise