갈란타민(Galantamine) 투여 후 순수 알츠하이머병 치매와 혼합성 치매 환자의 주의력, 일상생활능력 및 신경정신행동 증상에 대한 효과 평가

• 영문명: Effects of Galantamine Treatment on Attention, Activities of Daily Living, and Neuropsychiatric Symptoms between the Patients with Pure Alzheimer’s Disease and Mixed Dementia
• 발행기관: 대한노인정신의학회
• 저자명: 강효신(Hyo Shin Kang) 윤지혜(Ji Hae Yun) 안인숙(Inn Sook Ahn) 문유진(Yu Jin Moon) 황태영(Tae Young Hwang) 이영민(Young Min Lee) 김혜란(Hyeran Kim) 김도관(Doh Kwan Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제16권 제1호, 24~30쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Objectives：The purpose of this study was to compare the efficacy of galantamine treatment, especially attention ability between patients with pure Alzheimer’s disease (AD) and Mixed dementia (MD) during a 24-week trial. Methods：A total of 40 patients were recruited for this 24-week study. The effect of galantamine on attention was measured using Seoul Computerized NeuroCognitive Function Test (SCNT) and frontal functions test of Seoul Neuropsychological Screening Battery (SNSB). Patients’activities of daily living using the Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL) ; behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline and 24-week. Results：17 pure AD patients and 23 MD patients were analyzed in this study. Attention as measured by SCNT was not significantly different from baseline after 24 weeks of treatment in both groups. There was no significant difference between two groups in mean change from baseline in the SCNT, S-ADL, S-IADL and K-NPI scores at 24-week. Conclusion：Galantamine showed a therapeutic effect on cognition, activities of daily living, neuropsychiatric symptoms in pure AD and MD. Furthermore, Galantamine may specifically help to maintain attention and it may have positive effects on other cognitive and functional abilities.

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알츠하이머병 치매 혼합성 치매 갈란타민 주의력 치료 효과 Alzheimer’s disease Mixed dementia Galantamine Attention Clinical efficacy