유전성 암과 유전상담

• 영문명: Hereditary cancer and genetic counseling
• 발행기관: 대한의학유전학회
• 저자명: 정승용(Seung-Yong Jeong)
• 간행물 정보: 『대한의학유전학회지』제4권 제1호, 15~21쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.06.30

영문 초록

Hereditary syndromes cause approximately 5 to 10% of overall cancer cases. Cancer related with genetic syndromes are found elsewhere, including stomach, breast, colorectum, ovary, brain and so on. Because hereditary cancers are due to germline mutations, these patients have unique clinical features distinct from sporadic cancer. Generally these features include (ⅰ) early age-of onset of cancer, (ⅱ) frequent association with synchronous or metachronous tumors, (ⅲ) frequent bilateral involvement in paired organs (ⅳ) frequent association with other site tumors or characteristic clinical manifestation specific to each genetic syndrome. Due to these differences, the management strategy for patients with hereditary cancer is quite different from that for sporadic cancer. Additionally, there are important screening and surveillance implications for family members. Genetic counselling is prerequisite to these families for risk assessment by pedigree analysis, and guidance to clinical or genetic testing. The genes responsible for these syndromes has recently identified, as a result, genetic testing has become important determining factor in clinical decisions.

목차

서론

역사적 배경

유전성 종양 연구의 의의

유전성 종양의 특징 및 종류

유전성 종양의 원인 유전자

유전성종양 등록소

유전상담

참고문헌

키워드

Hereditary tumor Hereditary cancer Genetic counselling