노인성 기억력장애의 신경생물학

• 영문명: Neurobiology of Age-Associated Memory Impairment
• 발행기관: 대한노인정신의학회
• 저자명: 김승현(Seung-Hyun Kim) 신경호(Kyung-Ho Shin)
• 간행물 정보: 『노인정신의학』노인정신의학 제5권 제1호, 17~24쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2001.06.30

영문 초록

The diagnostic concept of age-associated memory impairment (AAMI) suggests that clinically recognized memory dysfunction could be a feature of normal aging. Although the memory impairment associated with aging is well recognized, underlying neurobiological mechanisms of cognitive decline remain unclear. There are a number of age-related structural and physiological changes in the brain that could have implications for cognitive decline in the elderly. The impact of these age-related changes in the brain on cognition has been studied using postmortem neurochemical, neuropathological findings or neuroimaging techniques. The available evidence from studies in aged and demented humans suggested that cognitive deficits related to aging might involve concomitant alterations of various neurochemical systems in several brain regions such as the striatum, the hippocampus or the cortex. It also seems that these alterations occur in a complex way which affects dopaminergic, glutamaterigc and serotonergic neurotnasmission in addition to the loss of cholinergic neurons in the basal forebrain, However, data collected to explain the mechanism of AAMI are still limited, the definite interpretation of these findings must await futher studies.

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노인성 기억력장애 노화 아세틸콜린 도파민 글루타메이트 Age-associated memory impairment Ageing Acetylchoine Dopamine Glutamate