비인두암의 방사선치료 결과

• 영문명: Results of Radiotherapy in Nasopharyungeal Cancer
• 발행기관: 대한방사선종양학회
• 저자명: 신병철(Byung Chul Shin) 마선영(Sun Young Ma) 문창우(Chang Woo Moon) 염하용(Ha Yong Yum) 정태식(Tae Sig Jeung) 유명진(Myung Jin Yoo)
• 간행물 정보: 『대한방사선종양학회지』제13권 제3호, 215~223쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1995.09.30

영문 초록

Purpose : The aim of this study was to assess the effectiveness, survival rate and complication of radiation therapy in nasopharyngeal cancer. Materials and Methods : From January 1980 to May 1989. Fifty patients who had nasoparyngeal carcinoma treated with curative radiation therapy at Kosin Medical Center were retrospectively studied. Thirty seven patients (74%) were treated with radiation therapy alone(Group Ⅰ) and 13 patients (26%) treated with combination chemotherapy and radiation(Group Ⅱ). Age distribution was 16-75 years (median: 45.8 years). In histologic type, squamous cell carcinoma was in 30 patients(60%), undifferentiated carcinoma in 17 patients(34%), and lymphoepithelioma in 3 patients(6%). According to AJCC staging system, 4 patients(8%) were in T₁, 13 patients (26%) in T₂. 20 patients (40%) in T₃, 13 patients(26%) in T₄ and 7 patients (14%) in T₀, 6 patients (12%) in N₁, 23 patients (46%) in N₂, 13 patients (28%) in N₃. Total radiation dose ranges were 5250-9200cGy(median: 7355cGy) in Group Ⅰ and 5360-8400cGy(median:6758Cgy) in Group Ⅱ. Radiotherapy on 4-6MV linear accelerator and/or 6-12MeV electron in boost radiation was given with conventional technique to 26 patients (52%), with hyperfractionation(115-120cGy/fr., 2times/day) to 16 patients (32%), with accelerated fractionation(160cGy/fr., 2times/day) to 8 patients(16%). In chemotherapy. 5 FU 1000mg daily for 5 consecutive days, pepleomycin 10mg on days 1 and 3, and cisplatin 100mg on day 1 were administered with 3weeks interval, total 1 to 3 cycles(average 1.8 cycles) prior to radiation therapy. Follow up duration was 6-140 months(mean: 58 months). Statistics was calculated with with Chi-square and Fisher's exact test. Results : complete local control rates in Group Ⅰ and Ⅱ were 75.7%, 69.2%, Overall 5 year survival rates in Group Ⅰ and Ⅱ were 56.8%, 30.8%. Five year survival rates by histologic type in Group Ⅰand Ⅱ were 52.2%, 14.3% in squamous cell carcinoma and 54.5%, 50% in undifferentiated carcinoma. Survival rates in Group Ⅰ were superior to those of Group Ⅱ though there were not statistically significant. In both group, survival rates seem to be increased according to increasing total dose of radiation up to 7500cGy, but not increased beyond it. There were not statistically significant differences in survival rates by age, stage, and radiation techniques in both group. Twenty four patients(48%) expericenced treatment failures. Complications were found in 12 patients(24%). The most common one was osteomyelitis(4 patients, 33.3%) involving mandible (3 patients) and maxilla(1 patient). Conclusion : Chemotherapy in combination with radiotherapy was found to be not effective to nasopharyngeal cancer and the survival rate was also inferior to that of radiation alone group though it was statistically not significant due to small population in chemotherapy combined group.

키워드

Nasoparyngeal cancer Radiotherapy Chemotherapy 5 year survival rate