A Case of Encephalitis Caused by Epstein-Barr Virus Infection

• 발행기관: 대한소아신경학회
• 저자명: Hyun-Jeong Do(도현정) Jong-Geun Baek(백종근) Jung-Sook Yeom(염정숙) Ji-Sook Park(박지숙) Eun-Sil Park(박은실) Ji-Hyun Seo(서지현) Jae-Young Lim(임재영) Chan-Hoo Park(박찬후) Hyang-Ok Woo(우향욱) Hee-Shang Youn(윤희상)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제17권 제2호, 247~252쪽, 전체 6쪽
• 주제분류: 의약학 > 소아과학
• 파일형태: PDF
• 발행일자: 2009.11.30

국문 초록

발열을 동반한 경련 이후 의식 저하를 주소로 내원한 환아에서 전형적인 전염성 단핵구증의 증상 및 비정형 림프구 혈증, 혈청학적 검사에서 양성 소견을 보여 EBV 감염에 의한 전염성 단핵구증의 합병증으로 발생한 뇌염으로 진단한 증례가 있어 보고하는 바이다.

영문 초록

An 11-year-old girl was diagnosed with encephalitis due to Epstein-Barr virus(EBV). She was admitted to our hospital due to convulsion and decreased consciousness after several days of fever, sore throat and headache. Cerebrospinal fluid analysis showed lymphocyte-dominant pleocytosis and markedly elevated levels of protein. Magnetic resonance imaging(MRI) finding was normal, except for marked leptomeningeal enhancement. Even though she had signs and symptoms of infectious mononucleosis, EBV infection could not be considered as the underlying cause of the encephalitis until IgM for the viral capsid antigen of EBV had been detected in her blood. After treatment with acyclovir, a high dose of methylprednisolone and intravenous immunoglobulin, the neurological symptoms improved rapidly. She has not suffered from any neurological complications in the four months since being discharged. EBV infection should be considered as the main etiology in cases of childhood encephalitis, although there is no evidence of infectious mononucleosis existed.

키워드

Infectious mononucleosis Epstein-Barr virus Infections Encephalitis