소아의 난치성 간질에서 Vigabatrin의 임상 효과

• 영문명: The clinical Effect of Vigabatrin in Refractory Pediatric Epilepsies
• 발행기관: 대한소아신경학회
• 저자명: 김기중(Ki Joong Kim) 이백희(Baeck Hee Lee) 황세희(Se Hee Hwang) 황용승(Yong Seung Hwang)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제1권 제2호, 91~96쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1993.12.20

영문 초록

The antiepileptic effect of vigabatrin in the children with refractory epilepsies has been investigated only to a limited extent. In order to assess the efficacy and safety of vigabatrin, 44 children with refractory epilepsies have been treated with vigabatrin in open, add-on studies. The mean duration of the administration was 9 months, and the mean dosage was 73.6mg/kg/day. The results were as follows; seizure free in 18.2% of the cases, 50-90% frequency reduction in 29.5%, and <50% frequency reduction or no change in 52.3%. The efficacy of vigabatrin was rated as 47.7%. The adverse effects were observed in 5 cases which were drowsiness, dizziness, diplopia and nausea. In all cases, however, the administration of vigabatrin could be continued.

키워드

Vigabatrin Refractory epilepsies