운동과 EPO(Erythropoietin)와의 관계

• 영문명: Relative in Exercise and EPO(Erythropoietin)
• 발행기관: 동아대학교 스포츠과학연구소
• 저자명: 강성훈(Kang Sung-Hwun) 이재규(Lee Jae-Gue) 양성우(Yang Sung-woo) 박일봉(Park Il-Bong) 차유림(Cha Yu-Rim) 오경식(Oh Kyung-Sik) 여남회(Yeo Nam-Hwoeh)
• 간행물 정보: 『스포츠과학연구논문집』제23집, 1~8쪽, 전체 8쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2005.12.01

영문 초록

  Erythropoietin is produced mainly in the kidney and regulates erythrocyte production. It binds to a cell surface receptor and leads to intracellular activation of several kinase pathways. EPO is a hypoxia-induced hormone that is essential for normal erythropoiesis. The production of recombinant human erythropoietin has revolutionized the treatment of anemia associated with chronic renal failure and chemotherapy. EPO has similar structure and signaling mechanisms to the family of type I cytokines and is markedly induced by hypoxia. EPO is synthesize by peritubular cells in the cortex-medullary border of the kidney and in the liver during fetal and neonatal development. A variety of other tissues have been reported to express erythropoietin including bore marrow macrophages, trophoblasts, breast glands, and astrocytes.
  Therefore, This study was invested relative in exercise and EPO, we had a conclusion as follows; 1) EPO is useful on polycythemia in test. 2) In patients with chronic renal insufficiency, r-HuEPO has also been shown to improve exercise capacity. 3) EPO has similar structure type I cytokines and induced by hypoxia.

목차

Abstract
Ⅰ. 서론
Ⅱ. 연구의 방법
Ⅲ. 결론
참고문헌

키워드

EPO(erythropoietin) hypoxia-induced cytokine