Growth Characteristics, Blood Biochemistry, Histology, and Metabolic Profile of Muscle and Different Tissues: Toxicity Study of Deoxynivaleno

• 발행기관: 한국축산식품학회
• 저자명: Jin Young Jeong Junsik Kim Minji Kim Sungkwon Park
• 간행물 정보: 『Food Science of Animal Resources』제45권 제6호, 1692~1709쪽, 전체 18쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2025.11.30

국문 초록

Deoxynivalenol (DON) toxicity causes oxidative stress, immunological disorders, and gastrointestinal injury, thereby reducing animal survival and productivity. Pigs are particularly susceptible to DON; therefore, clear standards for DON levels in animal feed are essential. Therefore, we investigated the growth characteristics, biochemistry, histology, and metabolite profiles of growing pigs fed dietary DON levels. Twelve pigs were randomized to one of four diets for 28 d: 1) CON, control group fed conventional diets; 2) T1, 1 mg; 3) T2, 3 mg; and 4) T3, 10 mg DON/kg conventional diet. The results revealed that the final body weight of the growing pigs in the T3 group was the lowest among all DON-treated groups (p<0.05). Additionally, the T3 group demonstrated the highest blood alkaline phosphate levels, whereas the T2 and T3 treatment groups exhibited reduced lipase levels compared to the other groups (p<0.01). Histological analysis showed that fibrosis increased in the muscle, liver, and other tissues, while apoptosis increased in the liver and ileum with increasing DON levels. Metabolomic profiling revealed that several metabolic pathways, such as purine metabolism, were involved in the weight loss induced by DON toxicity. In conclusion, our study suggests that DON levels above the maximum residue limits have adverse effects on growing pigs and that these effects are caused by altered metabolites.

목차

Introduction

Materials and Methods

Results

Discussion

Conclusion

Conflicts of Interest

Acknowledgements

Author Contributions

Ethics Approval

References

키워드

growing pig deoxynivalenol histology metabolite