Diagnostic Value of Electroencephalography Features and Serum Neurotrophic Factors in Differentiating Attention-Deficit/Hyperactivity Disorder Subtypes

• 발행기관: 대한신경정신의학회
• 저자명: Qiumin Zhao Rui Wang Yuanxin Lin Huilian Guo Yan Wang Jingwen Zhang Qinfen Zhang Shiyan Ji
• 간행물 정보: 『Psychiatry Investigation』제22권 제10호, 1164~1170쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.10.10

국문 초록

Objective Attention-deficit/hyperactivity disorder (ADHD) includes three subtypes: inattentive type (ADHD-I), hyperactive/impulsive type (ADHD-HI), and combined type (ADHD-C). Diagnosis mainly relies on subjective behavioral rating scales, lacking objective biomarkers. Electroencephalography (EEG) and serum neurotrophic factors—brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), and neurotrophin-3 (NTF3)—may aid subtype differentiation. This study evaluates their combined diagnostic value in children with ADHD. Methods A retrospective cohort of 322 children aged 6–12 years diagnosed with ADHD based on DSM-5 criteria was analyzed. EEG recordings were processed using Fast Fourier Transform to extract frequency band powers and P300 wave features. Serum levels of BDNF, NGF, GDNF, and NTF3 were measured via ELISA. Analysis of variance (ANOVA), multivariate regression, and ROC curve analyses were performed to assess diagnostic performance. Results ADHD-I patients exhibited elevated frontal θ power, higher θ/β ratios, prolonged P300 latency, and reduced P300 amplitude. ADHD-HI patients demonstrated increased β power in parietal regions and elevated NGF and NTF3 levels. Multivariate analysis identified θ power, θ/β ratio, NGF, NTF3, and P300 amplitude area as independent predictors for subtype differentiation. Combined EEG and serum markers yielded an area under the curve (AUC) (0.90) in distinguishing ADHD-I from ADHD-HI. Conclusion The integration of EEG features and neurotrophic factor profiles offers high diagnostic accuracy in differentiating ADHDI from ADHD-HI and moderate accuracy for the other subtype comparisons. These findings support the development of objective biomarker- based diagnostic tools for precision psychiatry in ADHD.

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INTRODUCTION

METHODS

RESULTS

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키워드

Attention deficit hyperactivity disorder EEG Neurotrophic factors ADHD subtypes θ/β ratio NGF