Enhanced Longevity and Immunity in Caenorhabditis elegans through Ingestion of Lactiplantibacillus plantarum SKO-001: A Multi-Omics Study

• 발행기관: 한국축산식품학회
• 저자명: Daniel Junpyo Lee Ju Young Eor Min-Jin Kwak Junbeom Lee An Na Kang Daye Mun Hyejin Choi Min-Geun Kang Youbin Choi Hee Seo Jae Yeong Ju Minho Song Jun-Mo Kim Jungwoo Yang Hyung Wook Kim Sangnam Oh Younghoon Kim
• 간행물 정보: 『Food Science of Animal Resources』제45권 제5호, 1293~1307쪽, 전체 15쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2025.09.15

국문 초록

Lactic acid bacteria are widely used as probiotics owing to their health-promoting properties. This study aimed to evaluate Lactiplantibacillus plantarum SKO-001 (SKO-001) as a probiotic candidate using Caenorhabditis elegans as a model organism. Our findings indicate that SKO-001 shows significantly stronger adhesive properties in C. elegans compared to Escherichia coli OP50, a standard dietary component used in laboratory settings for C. elegans, and the well-known probiotic Lacticaseibacillus rhamnosus GG (LGG). SKO-001 led to a significant increase in the longevity of C. elegans compared to those fed OP50. Additionally, pre-conditioning with SKO-001 significantly enhanced resistance to foodborne pathogenic bacteria. Transcriptomic analysis revealed that C. elegans fed with SKO-001 showed a significant increase in the expression of genes involved in the innate immune system, particularly those related to C-type lectins and lysozymes, compared to those fed with OP50. This suggests that feeding SKO-001 may boost immune responses against pathogens. Metabolomic analysis showed higher levels of lactic acid, L-valine, and L-isoleucine in C. elegans fed SKO-001 than in those fed OP50. Taken together, this research demonstrates the health-promoting potential of L. plantarum SKO-001 through multi-omics analysis, highlighting its capacity to extend lifespan and boost immune response in C. elegans.

목차

Introduction

Materials and Methods

Results

Discussion

Conclusion

References

키워드

Lactiplantibacillus plantarum Caenorhabditis elegans longevity immune response multi-omics analysis