The Association Between Childhood Trauma and Selective Serotonin Reuptake Inhibitor Treatment Outcomes in Adult Patients With Major Depressive Disorder

• 발행기관: 대한신경정신의학회
• 저자명: Yutong Deng Wen Bian Jingwen Sun Lijun Liu Shuzhe Zhou Qi Liu Tianmei Si Jing Wang Hongjun Tian Kerang Zhang Jing Wei Gang Wang Qiaoling Chen Gang Zhu Xueyi Wang Nan Zhang Xiaozhen Lv Xin Yu
• 간행물 정보: 『Psychiatry Investigation』제22권 제8호, 886~896쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.08.05

국문 초록

Objective The relationship between childhood trauma (CT) and the outcomes of selective serotonin reuptake inhibitor (SSRI) treatment for major depressive disorder (MDD) remains uncertain. The objective of this study is to investigate the overall association between CT and treatment outcomes in patients with MDD and the associations of different CT subtypes with the treatment outcomes of various MDD symptom dimensions. Methods A post hoc analysis of 285 adult patients with MDD from a multicenter, prospective study in China. Patients who completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF) and 8-week SSRI treatment were included. Depressive symptoms were evaluated using the 17-item Hamilton Rating Scale for Depression (HRSD-17) at baseline and at 2, 4, and 8 weeks. The primary outcome was defined as the percentage reduction in the total HRSD-17 score at the 8th week. The secondary outcomes included the percentage reduction in anhedonia and insomnia, derived from the HRSD-17. Linear regression analyses were conducted to evaluate the associations between the CTQ-SF score and treatment outcomes. Results Emotional neglect (EN) was associated with lower percentage reductions in HRSD-17 scores (β=-3.035, p=0.019), anhedonia (β=-4.227, p=0.044) and insomnia (β=-7.054, p=0.045) at 8 weeks. The total CTQ-SF score and other subscale scores were not significantly associated with treatment outcomes. Conclusion EN was associated with poorer SSRI treatment outcomes in MDD patients, with less improvement in overall depressive symptoms and anhedonia and insomnia in particular. EN should be prioritized in MDD treatment

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INTRODUCTION

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키워드

Depressive disorder major Anhedonia Sleep initiation and maintenance disorders Adverse childhood experiences Child abuse