Emerging role of circular RNAs in diabetic retinopathy

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Hyunjong Kim Juhee Ryu
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제29권 제4호, 385~397쪽, 전체 13쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Diabetic retinopathy (DR), a significant complication that affects the retina of individuals with diabetes, poses a severe threat to their visual health. DR is classified into stages ranging from non-proliferative to proliferative forms. As the disease progresses, pathological neovascularization and hemorrhage in the retina or vitreous can occur, potentially leading to vision impairment or blindness. Current treatments for DR include intravitreal injections of anti-vascular endothelial growth factor drugs and surgical interventions such as laser photocoagulation. However, these treatments are associated with various complications and side effects. Therefore, cellular and epigenetic studies are necessary to better understand the pathogenesis of DR, which may lead to the development of novel therapeutic strategies. Several studies have demonstrated the role of circular RNAs (circRNAs) in the pathogenesis and progression of DR. CircRNAs have been shown to regulate the expression of genes involved in the proliferation, differentiation, or angiogenesis of different retinal cells, thereby influencing their function. Therefore, this review aims to investigate the role of circRNAs in different retinal cell types in DR and evaluate their potential as diagnostic and therapeutic targets for the disease.

목차

DIABETIC RETINOPATHY (DR)

CIRCULAR RNA (circRNA)

ROLE OF circRNA IN DR

APPLICATION OF circRNA IN TREATING DR

DELIVERY STRATEGIES AND CELL TARGETING METHODS OF RNA-BASED DRUGS INTO THE RETINA

CONCLUSION

REFERENCES

키워드

Circular RNA Diabetic retinopathy Endothelial cells Noncoding RNA Retinal pigment epithelial cell