A Global Perspective on Incidence and Regional Trends of Opioid Use Disorders From 1990 to 2021

• 발행기관: 대한신경정신의학회
• 저자명: Tiantian Tuo Yupeng Chen Danyang Wang Jinna Liu Yujiao Wu Jiawen Wang
• 간행물 정보: 『Psychiatry Investigation』제22권 제6호, 668~677쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.06.17

국문 초록

Objective Opioid use disorders (OUDs) have become a significant global public health challenge. Despite extensive research on the opioid crisis, the trends in incidence and regional disparities remain inadequately understood. Methods Data were obtained from the Global Burden of Disease 2021, covering 204 countries and territories. OUDs incidence cases and rates per 100,000 population were analyzed over the study period. Trends were evaluated using the estimated annual percentage change (EAPC). Results Globally, OUDs cases increased by 49.25% from 1,301,551 (95% uncertainty interval [UI]: 1,077,634 to 1,598,053) in 1990 to 1,942,525 (95% UI: 1,643,342 to 2,328,363) in 2021. The incidence rate in 2021 was 24.62 per 100,000 population, with an EAPC of -0.25 (95% confidence interval: -0.39 to -0.1). Males had slightly higher rates than females (25.39 vs. 23.84 per 100,000). Individuals aged 15–49 years carried the highest burden, while older age groups showed the largest increases in cases. High-income North America reported the highest incidence rate in 2021 (123.28 per 100,000) and the largest case increase (425.34%). Among countries, the United States had the highest incidence rate increase (EAPC: 5.55), while Switzerland experienced the largest decline (EAPC: -4.33). A moderate positive correlation was identified between 2021 incidence rates and socio-demographic development (ρ=0.382, p<0.001). Conclusion This study highlights substantial global variability in OUDs trends, with significant differences across regions, sexes, age groups, and countries. Findings emphasize the need for tailored prevention and treatment strategies.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Opioid use disorders Incidence Global burden of disease Public health