학술논문
Aspirin-induced acetylation of APE1/Ref-1 enhances RAGE binding and promotes apoptosis in ovarian cancer cells
이용수 0
- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Hao Jin Yu Ran Lee Sungmin Kim Eun-Ok Lee Hee Kyoung Joo Heon Jong Yoo Cuk-Seong Kim Byeong Hwa Jeon
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제29권 제3호, 293~305쪽, 전체 13쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2025.05.01
4,360원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
The role of acetylated apurinic/apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref-1) in ovarian cancer remains poorly understood. Therefore, this study aimed to investigate the combined effect of recombinant human APE1/Ref-1 (rhAPE1/Ref-1) and aspirin (ASA) on two ovarian cancer cells, PEO-14, and CAOV3. The viability and apoptosis of ovarian cancer cells treated with rhAPE1/Ref-1 or ASA were assessed. Our results demonstrated that ASA induced rhAPE1/Ref-1 acetylation and widespread hyperacetylation in PEO-14 cells. Additionally, co-treatment with rhAPE1/Ref-1 and ASA substantially reduced cell viability and induced PEO-14 cell apoptosis, not CAOV3, in a dose-dependent manner. ASA increased the expression and membrane localization of the receptor for advanced glycation endproducts (RAGEs). Acetylated APE1/Ref-1 showed enhanced binding to RAGEs. In contrast, RAGE knockdown reduced cell death and poly(ADP-ribose) polymerase cleavage caused by rhAPE1/Ref-1 and ASA combination treatment, highlighting the importance of the APE1/Ref-1-RAGE interaction in triggering apoptosis. Moreover, combination treatment with rhAPE1/Ref-1 and ASA effectively induced apoptosis in 3D spheroid cultures of PEO-14 cells, a model that better mimics the tumor microenvironment. These results demonstrate that acetylated APE1/Ref-1 and its interaction with RAGE is a potential therapeutic target for ovarian cancer. Thus, the combination of ASA and APE1/Ref-1 may offer a promising new strategy for inducing cancer cell death.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
키워드
해당간행물 수록 논문
- Aspirin-induced acetylation of APE1/Ref-1 enhances RAGE binding and promotes apoptosis in ovarian cancer cells
- Haloperidol, a typical antipsychotic, inhibits 5-HT₃ receptor-mediated currents in NCB-20 cells: a whole-cell patch-clamp study
- Shikonin attenuates blood–brain barrier injury and oxidative stress in rats with subarachnoid hemorrhage by activating Sirt1/Nrf2/HO-1 signaling
- Lactobacillus johnsonii JERA01 upregulates the production of Th1 cytokines and modulates dendritic cells-mediated immune response
- Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis
- Enhancing doxorubicin’s anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor
- Quetiapine competitively inhibits 5-HT₃ receptor-mediated currents in NCB20 neuroblastoma cells
- Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma
- Identification of telomere-related diagnostic markers in osteoarthritis based on bioinformatics analysis and machine learning
참고문헌
관련논문
의약학 > 의학일반분야 BEST
더보기의약학 > 의학일반분야 NEW
- Quetiapine competitively inhibits 5-HT₃ receptor-mediated currents in NCB20 neuroblastoma cells
- Haloperidol, a typical antipsychotic, inhibits 5-HT₃ receptor-mediated currents in NCB-20 cells: a whole-cell patch-clamp study
- Hyaluronan-mediated motility receptor-mediated aerobic glycolysis enhances stem-like properties and chemoresistance in lung adenocarcinoma
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!