The Influence of Life Stress and Sleep Disturbance on White Matter Integrity

• 영문명: The Influence of Life Stress and Sleep Disturbance on White Matter Integrity
• 발행기관: 대한신경정신의학회
• 저자명: Minjeong Kim Jiye Lee Nambeom Kim Yunjee Hwang Kyung Hwa Lee Jooyoung Lee Yu Jin Lee Seog Ju Kim
• 간행물 정보: 『Psychiatry Investigation』제20권 제5호, 439~444쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.05.31

영문 초록

Objective: This study investigated whether sleep and stress mutually interact to induce changes in white matter integrity. Methods: Diffusion tensor imaging (DTI) was conducted on 36 participants (male=22, female=14; mean age=38.33±12.78 years). Participants were divided into three groups depending on their sleep quality and stress levels: poor sleepers with stress, poor sleepers without stress, and good sleepers. Sleep quality and stress level were evaluated using the Pittsburgh Sleep Quality Index and the Life Experiences Survey, respectively. Fractional anisotropy (FA) values were calculated employing DTI tractography. Results: After controlling for age and sex, poor sleepers with stress exhibited a lower FA of the left inferior cerebellar peduncle (ICP) than did poor sleepers without stress (t=2.81, p=0.02). Poor sleepers without stress showed a higher FA of the right middle longitudinal fasciculus (MdLF) than did good sleepers (t=3.35, p=0.006). Conclusion: The current study reports the effects of sleep, stress, and their interaction on the white matter integrities of the ICP and MdLF. ICP change seems to be associated with sleep disturbances related to stress, while MdLF change would be associated with sleep disturbances unrelated to stress.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Stress Sleep Inferior cerebellar peduncle Middle longitudinal fasciculus Diffusion tensor image