학술논문
Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR): Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells
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- 영문명
- Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR): Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Jee Na Hwang Hwa-Jin Jung Young Rok Seo
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제8권 제6호, 351~354쪽, 전체 4쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2004.01.01
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국문 초록
영문 초록
The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells.
목차
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