Decreased Expression of PTEN in Olfactory Bulb of Rat Pub after Naris Closure

• 영문명: Decreased Expression of PTEN in Olfactory Bulb of Rat Pub after Naris Closure
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Jaeyoung Cho Sang-Hyun Lee Geon Hee Lee Wanjoo Chun Yee-Tae Park,
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제8권 제1호, 17~20쪽, 전체 4쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2004.01.01

영문 초록

PTEN (phosphatase and tensin homolog) is a dual specific phosphatase antagonizing phosphoinositide 3-kinase activity, and has first been cloned as a tumor suppressor for glioma. Although the role of PTEN as a tumor suppressor has been well studied, little is known about signaling mechanisms regulating expression and/or activity of PTEN in the central nervous system. In this study, we investigated whether PTEN expression is regulated by sensory deprivation. P5 rat pups were unilaterally naris-closed, and olfactory bulbs were immunohistochemically analyzed with PTEN antibody at the 7^th day after naris closure. PTEN immunoreactivity was found to be down-regulated in both glomerular, external plexiform and subependymal cell layers, suggesting that odor deprivation signals down-regulate expression of PTEN in the olfactory bulb. To the best of our knowledge, this is the first report to suggest that PTEN expression is regulated by sensory deprivation signals in neonatal rats.

키워드

PTEN (phosphatase and tensin homolog) Olfactory bulb Naris closure