The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

• 영문명: The Preventive Effects of Bcl-2 and Bcl-x_L on Lovastatin-induced Apoptosis of C6 Glial Cells
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Jae Won Choi Jong Min Lee Young Jun Oh
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제6권 제5호, 235~240쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2002.01.01

영문 초록

It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-x_L in C6 glial cells. Overexpression of human Bcl-2 or Bcl-x_L prevented lovastatin (25μM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-x_L overexpression. These results suggest that Bcl-2 and Bcl-x_L can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.

키워드

Lovastatin Apoptosis C6 Bcl-2 Bcl-x_L