Decrease in Ca2 Storage in the Cardiac Sarcoplasmic Reticulum of Diabetic Rat
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- 영문명
- Decrease in Ca2 Storage in the Cardiac Sarcoplasmic Reticulum of Diabetic Rat
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Won-Tae Kim Hae Won Kim Young-Kee Kim
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제2권 제6호, 725~732쪽, 전체 8쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 1998.01.01
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국문 초록
영문 초록
In order to elucidate the molecular mechanism of the intracellular Ca2 overload frequently reported from diabetic heart, diabetic rats were induced by the administration of streptozotocin, the membrane vesicles of junctional SR (heavy SR, HSR) were isolated from the ventricular myocytes, and SR Ca2 uptake and SR Ca2 release were measured. The activity of SR Ca2-ATPase was 562⁑14 nmol/min/mg protein in control heart. The activity was decreased to 413⁑30 nmol/min/mg protein in diabetic heart and it was partially recovered to 485⁑18 nmol/min/mg protein in insulin-treated diabetic heart. A similar pattern was observed in SR 45Ca2 uptakes; the specific uptake was the highest in control heart and it was the lowest in diabetic heart. In SR 45Ca2 release experiment, the highest release, 45% of SR 45Ca2, was observed in control heart. The release of diabetic heart was 20% and it was 30% in insulin-treated diabetic heart. Our results showed that the activities of both SR Ca2-ATPase and SR Ca2 release channel were decreased in diabetic heart. In order to evaluate how these two factors contribute to SR Ca2 storage, the activity of SR Ca2-ATPase was measured in the uncoupled leaky vesicles. The uncoupling effect which is able to increase the activity of SR Ca2-ATPase was observed in control heart; however, no significant increments of SR Ca2-ATPase activities were measured in both diabetic and insulin-treated diabetic rats. These results represent that the Ca2 storage in SR is significantly depressed and, therefore, Ca2-sequestering activity of SR may be also depressed in diabetic heart.
목차
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