심근에 작용하는 수종 약물이 쥐의 심근의 Regenerative Ca++ Release 에 미치는 영향

• 영문명: Effects of Several Cardioactive Agents on the Regenerative Ca⁺⁺ Release in the Mechanically Disrupted Cardiac cells
• 발행기관: 대한생리학회
• 저자명: 강두희(Kang, Doo-Hee) 이중우(Lee, Joong-Woo)
• 간행물 정보: 『대한생리학회지』제11권 제2호, 9~16쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1977.12.31

영문 초록

The present experiment was conducted to see whether or not several cardioactive agents influence the regenerative Ca⁺⁺ release in the mechanically disrupted cardiac cells. The mechanically disrupted cardiac cells were prepared by the method of Kerrick and Best from the ventricle of rat. The tension development of the disrupted cardiac cells was measured with a mechanoelectric transducer (RCA 5734). The results were summarized as follows 1) 2 mM caffeine enhanced the regenerative Ca⁺⁺ release, whereas 2 mM Procaine inhibited the Ca⁺⁺ release as reported by other investigators. 2) Epinephrine at concentrations of 10^-7, 10^-6 and 10^-5M increased the regenerative Ca⁺⁺ release significantly but showed a poor dose response on the Ca⁺⁺ release. 3) Propranolol showed no effect on the regenerative Ca⁺⁺ release when studied alone. Furthermore, it showed no antagonistic effect on an increased regenerative Ca⁺⁺ release induced by epinephrine. 4) Other cardioactive agents such as acetylcholine, ouabain, isoproterenol and c-AMP at concentrations of 10^-6M showed no effect on the regenerative Ca⁺⁺ release. From the above results, it may be concluded that the cardioactive actions of these agents are not related directly to the process of regenerative Ca⁺⁺ release.