Clonidine이 고양이 척수후각세포의 Activity에 미치는 효과

• 영문명: Effect of Clonidine on the Dorsal Horn Cell Activities in the Cat
• 발행기관: 대한생리학회
• 저자명: 지용철(Chi, Yong-Chul) 김진혁(Kim, Jin-Hyuk) 고상돈(Koh, Sang-Don) 신홍기(Shin, Hong-Kee) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제22권 제1호, 89~100쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1988.06.30

영문 초록

Effect of clonidine on the dorsal horn cell responses to mechanical stimulations were studies in 3 spinalized cats and 10 cats with intact spinal cord. The type of dorsal horn cells was determined according to their response patterns to four graded mechanical stimulations (brush, pressure, pinch and squeeze) applied to the respective receptive fields. In the present study the results obtained only from the wide dynamic range (WDR) cells were included. The responses of the WDR cells to noxious mechanical stimuli were selectively suppressed following intravenous administration of clonidine into the experimental animals. The clonidine-induced changes in responses of the WDR cells to mechanical stimulation were not affected by naloxone or propranolol whereas effect of clonidine on WDR cell responses was almost completely abolished after intravenous administration of yohimbine. Also in the spinalized cats results parallel to those observed in cats with intact spinal cord were obtained. The results of present study strongly implies that analgesic action of clonidine can be mediated through excitation of α₂-adrenoceptor even at the spinal cord level without supraspinal mechanism.

키워드

Clonidine α_2-antagonist WDR cell activity Spinal animal Analgesia