Low-Dose Acetazolamide in the Treatment of Premenstrual Dysphoric Disorder: A Case Series

• 발행기관: 대한신경정신의학회
• 저자명: Gabriele Sani Georgios D. Kotzalidis Isabella Panaccione Alessio Simonetti Lavinia De Chiara Antonio
• 간행물 정보: 『Psychiatry Investigation』제11권 제1호, 95~101쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2014.01.31

영문 초록

The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do not respond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergic transmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder and one with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125 mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month followup. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergic mechanisms may be involved in counteracting PMDD symptoms.

목차

INTRODUCTION

CASE

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

키워드

Premenstrual dysphoric disorder Sulfonamide diuretics Acetazolamide GABA transmission