폐쇄성 수면무호흡증 환자에서 신경인지기능 이상과 수면요인과의 관련성

• 영문명: Neurocognitive Dysfunction Related with Sleep Factors in Patients with Obstructive Sleep Apnea
• 발행기관: 대한신경정신의학회
• 저자명: 김성재 이정희
• 간행물 정보: 『신경정신의학』제45권 제4호, 295~306쪽, 전체 12쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2006.07.30

영문 초록

We aimed to review the neurocognitive dysfunction in obstructive sleep apnea (OSA) and to clarify its relationship with hypoxemia, sleep fragmentation and daytime sleepiness. The disordered breathing during rapid-eye movement sleep (REMS) was recognized as a correlate of the neurocognitive impairment in OSA. Among sleep characteristics of OSA, intermittent hypoxemia (IH) was discussed in terms of possible mechanisms such as the abnormality of ventilatory drive, vasculopathy and oxidative stress. Specific brain damages in the frontal lobe and the hippocampus was also addressed. The OSA patients often experience decline in multiple domains of neurocognitive function. Particularly, decline in attention, executive function, constructional ability, or psychomotor performance was reported to be highly associated with IH. There have been some debates on the effect of daytime sleepiness on neurocognitive function. Persistent impairment in executive function and psychomotor performance after the treatment of OSA suggests an irreversible brain damage. A standardized instrument needs to be developed to evaluate each domain of neurocognitive function, and to measure the severity of OSA and its treatment response. Further studies on the relationship of REMS with the neurocognitive function are necessary.

목차

서 론

신경인지기능과 관련된 OSA의 수면특성의 분류

OSA와 대뇌병리

신경인지기능의 세부영역별 감퇴

결 론

REFERENCES

키워드

Obstructive sleep apnea Neurocognitive function Hypoxemia REM sleep