학술논문
A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Karen M. Jimé nez Angela J. Pereira Morales Diego A. Forero
- 간행물 정보
- 『Psychiatry Investigation』제15권 제4호, 402~406쪽, 전체 5쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2018.04.30
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국문 초록
영문 초록
Objective-The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504.
Methods-A total of 239 young Colombian subjects were evaluated with the Patient Health Questionnaire-9 (PHQ-9) scale and geno-typed for the rs686 polymorphism. A linear regression model, corrected by age and gender, was used.
Results-A significant association between the rs686 polymorphism and PHQ-9 scores was found, under a dominant genetic model (p=0.0094).
Conclusion-These results provide novel evidence about the growing role of inherited variants in binding sites for brain-expressed miRNAs on depressive symptomatology
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
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