1차 틀린 믿음 과제를 이용한 한국인 정신분열병 환자의 마음이론 관련 기능적 뇌자기공명영상 연구

• 영문명: An fMRI Study Regarding the ‘Theory of Mind’ in Korean Schizophrenic Patients Using a First Order False Belief Task
• 발행기관: 대한신경정신의학회
• 저자명: 오인경 손정우 이상익 신철진 김시경 김혜리 이승복 박 민 유제춘 김영랑 최영락 정우림 김민정 정효선2 윤효운
• 간행물 정보: 『신경정신의학』제49권 제3호, 312~323쪽, 전체 12쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.05.30

영문 초록

Objectives The aim of this study was to investigate brain activation during a Korean languagebased‘ theory of mind (TOM)’ task and fMRI in Korean schizophrenic patients. MethodsZZFourteen Korean schizophrenic patients and 15 normal controls participated in this study. For all participants, several clinical states and psychosocial functions were evaluated. The subjects were then scanned while performing Korean language-based fMRI tasks. The tasks were comprised of conditions-first order false belief (TOM task), physical causality, and unrelated situations. Imaging data were analyzed using SPM2 software (uncorrected p<0.005, extent threshold κ=10). Results 1) Compared with the control group, the patient group showed significantly poorer performance on the TOM task, and no significant correlation between TOM and empathic abilitiesy. 2) In the patient group, there were no significantly activated brain regions associated with the TOM task as compared to the physical causality task. With respect to between-group differences, the patient group showed significantly less activation of the left medial frontal region (primarily BA 8) and signifcantly different activation of the left precuneus (BA 7) associated with the TOM task. Conclusion These results suggest that Korean schizophreniac patients show different brain activity associated with TOM functions, especially with respect to the Korean language-based first order false belief tasks

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REFERENCES

키워드

Schizophrenia Theory of mind First order false belief task fMRI