기분 장애 환자에서의 P50 청각유발전위 연구

• 영문명: Study on the P50 Auditory Evoked Potential in Mood Disorder Subjects
• 발행기관: 대한신경정신의학회
• 저자명: 김건종 이남영 안용민 강웅구
• 간행물 정보: 『신경정신의학』제49권 제5호, 516~522쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.09.30

영문 초록

Objectives Diminished suppression of the P50 response, a consistent finding in schizophrenia, has also been reported in patients with bipolar disorder. It is a promising endophenotype for schizophrenia, but its relationship to genetic liability in mood disorder is controversial. The present study investigated event-related brain potential (ERP) indices of auditory processing and sensory gating in mood disorder and subgroups of patients with bipolar disorder with or without a history of psychosis using the P50 dual-click procedure. Methods The P50 auditory evoked potential response to paired stimuli was measured in 77 subjects with mood disorder (58 with bipolar disorder and 19 with major depressive disorder) and 28 healthy controls. P50 parameters were compared between groups. ResultsZZP50 suppression in patients with mood disorder did not differ from that in the healthy subjects. Except for S1 latency, there were no significant differences in P50 parameters between the diagnosis groups. In patients with bipolar disorder, a history of psychosis made no difference to P50 parameters. Conclusion P50 was not significantly impaired in patients with mood disorder. There has been much debate on the meaning of P50, and more studies including longitudinal within-subjects studies are warranted to clarify the meaning and mechanisms of P50.

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키워드

P50 auditory evoked potential Mood disorder Endophenotype Sensory gating Sensory integration