양성 및 음성증상 정신분열병환자에서 Sulpiride 투여후의 임상적 호전도와 혈중 약물농도와의 관계

• 영문명: The Clinical Effects and Serum Concentrations of Sulpiride in Positive and Negative Symptom Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 안윤영 한규희
• 간행물 정보: 『신경정신의학』제32권 제6호, 983~990쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1993.11.30

영문 초록

It has been suggested that positive and negative symptom schizophrenia have different pathophysiology and cause. The authors administered fixed dosage of sulpiride, an atypical antipsychotics, to schizophrenic patients (DSM-III-R) as scheduled for the duration of 6 weeks. Every 2 weeks the psychotic symptoms were rated with Positive and Negative Syndrome Scale (PANSS). The serum neuroleptic levels measured by NRRA were correlated with oral dosage(R2=0. 36336)，but not with clinical improvement

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Serum sulpiride levels Schizophrenia DSM-III-R Positive symptom Negative symptom PANSS