自然產物 精神病藥劑의 Dopamine-2 및 Serotonin-2 受容體 結合

• 영문명: Dopaxnine-2 and Serotonin-2 Receptor Bindings in Antipsychotic Medicines from Natural Products
• 발행기관: 대한신경정신의학회
• 저자명: 鄭寅元 金承律 金應國
• 간행물 정보: 『신경정신의학』제31권 제5호, 856~868쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1992.09.30

영문 초록

In an effort to establish the theoretical basis of traditional medicine in Korea’ the radioligand receptor binding study was conducted with natural products. Some natural products used as antipsychotics in traditional medicine displaced the radiolabeled probes from the receptors of dopamine-2 and serotonin-2 in central nervous system of male Sprague-Dawley rats. The results were as follows; 1) Reviewing the books about the oriental medicine including Dong Eui Bo Gam, there were over 200 natural products in prescriptions and mono-drug regimen treating the mental disorders, mainly psychosis. 2) For D 2 receptor analysis with 3[H]-spiperone as radio-ligand, the striatal tissues o f male Sprague-Dawley rats were used. The Bmax of the receptor was 146.54fmole/mg protein and the Kd was 0.38 nM as the basic data of studies. Of the 36 natural products, Polygala tenuifolia only had shown the affinity to the D 2 receptor and m ade the dilution-binding curve. 3) The 5 H T2 receptor binding study was conducted with 3[H ]-ketanserin and the cortical tissue. The Bmax and Kd were 57.34 fmole/mg protein, 0.08 nM, respectively. There was Polygala tenuifolia, M achilus thunbergii, Erigeron canadensis, and Citrus unshiu which showed the affinities and the dilution binding curves. 4) There could be related follow-up studies. One is to establish the reference books about biochemical structures and pharmacological characteristics o f com ponents of natural products in traditional medicine. Another is to screen other natural products by radio-ligand receptor binding study. And the other is to identify the pharmacological and biochemical characteristics of the effective com ponents of natural products which show affinities to the receptors in this study.

목차

序 論

연구 방법

연구 결과

고 안

要 約

References

키워드

Antipsychotic medicines Natural products Dopamine-2 receptor Serotenin-2 receptor