Alprazolam 의 항불안 및 항우울 효과에 대한 이중맹 치험

• 영문명: A Double Blind Clinical Study on Antianxiety and Antidepressant Effects of Alprazolam
• 발행기관: 대한신경정신의학회
• 저자명: 민성길 이호영 연규월
• 간행물 정보: 『신경정신의학』제25권 제1호, 65~69쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1986.02.28

영문 초록

Forty —seven out patients with generalized anx- iety disorder by DSM - III criteria were randomly assigned to receive ether alprazolam or placebo. The dosage of alprazolam was 1.5 to 2.0 mg per day and treatment period was 2 weeks. Clinical evaluation with Hamilton’s anxiety scale and depression scale were done on the double blind basis before( baseline} and after treatment. The changes from baseline were compared between placebo and active dm.g groups. The result of study showed that alprazolam produced significantly more clinical improvement than did placebo in both anxiety and depression The side effects as anticholinergic effects were not reported for alprazolam as well as placebo. To-lerance and withdrawal symptoms were not noted during the study period of 4 weeks,

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