대장암의 수술 전후 면역관련인자의 변화에 대한 전향적연구 - 개복수술과 복강경수술의 비교

• 영문명: Comparison of Immune Related Factors between Open and Laparoscopic Colectomy in Colorectal Cancer Patients
• 발행기관: 개인저작물
• 저자명: 박치민(Chi Min Park) 강신재(Shin Jea Kang) 한상아(Sang Ah Han) 윤성현(Seong Hyeon Yun) 이우용(Woo Yong Lee) 전호경(Ho Kyung Chun)
• 간행물 정보: 『개인저작물 - 의학』대한내시경복강경외과학회지 제9권 1호, 5~14쪽, 전체 10쪽
• 주제분류: 의약학 > 개인저작물
• 파일형태: PDF
• 발행일자: 2006.01.01

영문 초록

Purpose: The Purpose of this study was to evaluate the perioperative change of immune related factors in laparoscopic coletomy compared with conventional open colectomy for the patients with colorectal cancer.
Methods: From April to August 2002, 13 patients who underwent elective laparoscopic colectomy were compared to 13 patients who received elective open colectomy for colorectal cancer. Prospective controlled study was done by analyzing the inflammatory factor(ESR, CRP, WBC) the cellular immunity (T, B, T4, T8, lymphocyte, NK cell, CD4/CD8 ratio) and the humoral immunity (IgG, IgA, IgM, C3, C4) preoperatively, on the first and fifth operative day respectively.
Results: The clinicopathologic characteristcs were not different between two group, but the opreation time was taken longer in the laparoscopic colectomy than open colectomy significantly (p=0.001). Acute inflammatory factors and humoral immunity were not different between two groups statistically. In cellular function, all factors were decreased in both group at immediately postoperative period, but B lymphcyte and NK cell were not change with statistic significance in the lapaoscopic group. At postoperative fifth day, total lymphocyte count, T, B and T4 lymphcyte were recovered up to preoperative level in the laparocscopic group, but not in open surgery group. 3 years disease free survival rate was not different between two group.
Conclusion: Postoperative cellular immunity was seemed to be better preserved and recovered after laparoscopiv colectomy than convetioanl open colectomy. Futher study should be carried out to define the immune changes of laparoscopic surgery compared with open surgery with more parameter and patients.

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키워드

Colorectal cancer Colectomy Laparoscopic surgery Cellular immunity Humoral immunity 대장암 대장절제술 복강경 수술 세포 면역성 체액면역성