별모양세포종에서 Bcl-2, Bax의 발현과 Ki-67 증식지수 - 예후와의 관계

• 영문명: Bcl-2 and Bax Expression and Ki-67 Proliferative Index in Astrocytic Tumors : in Relation to Prognosis
• 발행기관: 개인저작물
• 저자명: 김세윤(Sei-Yoon Kim) 정순희(Soon-Hee Chung) 김헌주(Hun-Joo Kim) 황금(Kum Whang) 한용표(Young-Pyo Han) 홍순기(Soon-Ki Hong)
• 간행물 정보: 『개인저작물 - 공학』J Korean Neurosurg Soc Vol.35, 465~471쪽, 전체 7쪽
• 주제분류: 공학 > 개인저작물
• 파일형태: PDF
• 발행일자: 2004.05.01

영문 초록

Objective : We report a retrospective investigation of the prognostic value of bcl-2 and bax expression, and Ki-67 proliferative index in 42 astrocytic tumors.
Methods : We classified the astrocytic tumors and reviewed the clinical information and survival time. The sections were taken from surgically resected paraffin-embedded tissue and performed immunohistochemical stains for bcl- 2, bax and Ki-67.
Results : The immunohistochemical stain for bcl-2 revealed a positivity in only two(4.76%) among forty-two cases. The immunostain for bax was positive in 35 cases(83.3%). However, the correlation between bcl-2 & bax expression and age, sex, tumor location, size, and histologic grade was not found. By Kaplan-Meier analysis, bcl-2 & bax expression and survival time in astrocytic tumors was no significance in log rank test(p>0.05). There were prognostic values between Ki-67 LI and histologic grade and between Ki-67 LI and survival time, respectively(p<0.05).
Conclusion : Bcl-2 and bax are not significant, whereas Ki-67 LI is suggested as a significant prognostic factor, associated with histologic grade and survival time of astrocytic tumors.

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키워드

Astrocytic tumor Bcl-2 Bax Ki-67 Prognostic factor