Radiotherapy omission in low-risk, early-stage breast cancer: a single-center, real-world comparative analysis

• 발행기관: 대한방사선종양학회
• 저자명: Youngju Song Sae Byul Lee Su Ssan Kim Seung Do Ahn Jong Won Lee Jinhong Jung
• 간행물 정보: 『대한방사선종양학회지』제43권 제3호, 151~160쪽, 전체 10쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2025.09.30

국문 초록

Purpose: This study aimed to compare treatment outcomes between patients who received adjuvant radiotherapy (RT) and those who did not, in a cohort of patients with low-risk, early-stage breast cancer. Materials and Methods: Postmenopausal women with pT1N0/Nx, grade 1-2, hormone receptor-positive, human epidermal growth factor 2-negative, and Ki-67 ≤ 20% breast cancer who underwent breast-conserving surgery and adjuvant endocrine therapy between 2010 and 2020 were included. The decision on RT omission was based on physician assessment and patient preference. The primary outcome was cumulative incidence of disease recurrence. Secondary outcomes included locoregional recurrence, overall survival, and breast cancer-specific survival. Results: Of the 742 patients, 707 received adjuvant RT (postoperative radiation therapy [PORT] group) and 35 did not (RT omission group). Baseline characteristics were generally similar; however, the RT omission group was older (median age, 76 years; range, 68 to 85 years) than the PORT group (median age, 62 years; range, 55 to 87 years). After a median follow-up of 60 months in the PORT group and 52 months in the RT omission group, the 5-year cumulative incidence of disease recurrence was 1.28% and 0%, respectively (Gray’s test, p = 0.305). Locoregional recurrence occurred in seven patients (1.0%) in the PORT group, whereas no locoregional recurrences were observed in the RT omission group. The results remained consistent after propensity score matching. Conclusion: Low-risk, early-stage breast cancer patients exhibited comparable disease recurrence and survival rates regardless of the RT status. Our study underscores the necessity for further investigation into RT omission in carefully selected patients.

목차

Introduction

Materials and Methods

Results

Discussion and Conclusion

Statement of Ethics

Conflict of Interest

Acknowledgments

Funding

Author Contributions

Data Availability Statement

Supplementary Materials

References

키워드

Breast neoplasm Low-risk Early-stage Adjuvant radiation therapy Omission

참고문헌

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• N Engl J Med
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• J Clin Oncol
• Eur J Cancer
• J Clin Oncol
• Lancet
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