Effects of close surgical margins on prognosis and recurrence of oral squamous cell carcinoma

• 발행기관: 대한구강악안면외과학회
• 저자명: Kavitha Prasad A. Nityasri Jugal Ashok Toprani Shashank Madhusudan
• 간행물 정보: 『대한구강악안면외과학회지』제51권 제3호, 161~167쪽, 전체 7쪽
• 주제분류: 의약학 > 일반외과학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Objectives: To assess the relationships of close surgical margins with recurrence and prognosis of oral squamous cell carcinoma (OSCC). Materials and Methods: This retrospective study consisted of 198 patients who were diagnosed with OSCC based on histopathology. All patients underwent wide local tumor resection and neck dissection, followed by or preceded by chemotherapy and/or radiotherapy. The tumor variables assessed were the pathological stage of disease, involvement site, tumor size, margin status, tumor differentiation, bone involvement if any, presence of lymphovascular or perineural invasion, adjuvant therapies including chemotherapy and radiotherapy, lymph node involvement, and ratio. Results: The outcome of the disease based on margins was statistically significant, with close mar- gins associated with increased risk of disease fatality. Recurrence was associated with close margins, followed by adequate margins, and the relation-ship was significant within the first 2 years. Tumor stage and size significantly correlated with margin status. Close surgical margins correlated with one positive lymph node. Conclusion: Close surgical margins are strong predictors for determining prognosis of OSCC.

목차

I. Introduction

II. Materials and Methods

III. Results

IV. Discussion

V. Conclusion

References

키워드

Oral squamous cell carcinoma Surgical margins Prognostic factor Recurrence