역학연구에서의 비역치선형모델: 방사선 노출 사례

• 영문명: The Linear No-Threshold Model in Epidemiological Studies: An Example of Radiation Exposure
• 발행기관: 한국환경보건학회
• 저자명: 이원진(Won Jin Lee)
• 간행물 정보: 『한국환경보건학회지』제50권 제4호, 229~236쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2024.08.31

국문 초록

The linear no-threshold (LNT) model is an assumption that explains the dose-response relationship for health risks, allowing for linear extrapolation from high doses to low doses without a threshold. The selection of an appropriate model for low-dose risk evaluation is a critical component in the risk assessment process for hazardous agents. This paper reviews the LNT model in light of epidemiological evidence from major international consortia studying ionizing radiation. From a scientific perspective, substantial evidence supporting the LNT model has been observed in epidemiological studies of low-dose ionizing radiation exposure, although some findings suggest non-linear dose relationships for certain cancer sites and variations across populations. From a practical standpoint, the LNT remains the most useful model for radiation protection purposes, with no alternative dose-response relationship proving more appropriate. It is important to note that the LNT model does not directly reflect the magnitude of risk at the population level, and this distinction should be clearly communicated to the public. While applying the LNT model as the principal basis for radiation protection, continuous research into various dose-response relationships is crucial for advancing our understanding

키워드

Dose-response epidemiology ionizing radiation LNT risk estimation