본문 바로가기

추천 검색어

실시간 인기 검색어

학술논문

Growth hormone treatment for children with mucopolysaccharidosis I or II

이용수  9

영문명
Growth hormone treatment for children with mucopolysaccharidosis I or II
발행기관
대한의학유전학회
저자명
Minji Im Chiwoo Kim Juyoung Sung Insung Kim Ji-Hoon Hwang Min-Sun Kim Sung Yoon Cho
간행물 정보
『대한의학유전학회지』제20권 제2호, 60~69쪽, 전체 10쪽
주제분류
의약학 > 기타의약학
파일형태
PDF
발행일자
2023.12.31
4,000

구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.

1:1 문의
논문 표지

국문 초록

영문 초록

Purpose: Despite enzyme replacement therapy (ERT) and/or allogeneic hematopoietic stem cell transplantation, individuals with mucopolysaccharidosis (MPS) I or II often experience significant growth deficiencies. This study aimed to assess the safety and efficacy of recombinant human growth hormone (hGH) treatment in children diagnosed with MPS I or II. Materials and Methods: A total of nine pediatric patients—four with MPS I and five with MPS II—underwent treatment with ERT and hGH at Samsung Medical Center. Results: The mean hGH dose administered was 0.26±0.03 mg/kg/week. In the MPS I group, three patients showed an increase in height Z-score from -4.09±0.83 to -3.68±0.43 after 1 year of hGH treatment, and to -3.10±0.72 by the end of the hGH regimen. In the MPS II group, while the height Z-score of four patients decreased according to standard growth charts, it improved from 1.61±1.79 to 2.71±1.68 based on the disease-specific growth chart through hGH treatment. Two patients discontinued hGH treatment due to lack of efficacy after 22 and 6 months each of treatment, respectively. No new-onset neurological symptoms or necessity for prosthetic or orthopedic surgery were reported during hGH treatment. Conclusion: This study provides insights into the impact of hGH on MPS patients, demonstrating its potential to reverse growth deceleration in some cases. Further research is needed to explore the long-term effects of hGH on changes in body composition, muscle strength, and bone health in this population.

목차

Introduction
Materials and Methods
Results
Discussion
Acknowledgements
Funding
Authors' Contributions
References

키워드

해당간행물 수록 논문

참고문헌

교보eBook 첫 방문을 환영 합니다!

신규가입 혜택 지급이 완료 되었습니다.

바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!

교보e캐시 1,000원
TOP
인용하기
APA

Minji Im,Chiwoo Kim,Juyoung Sung,Insung Kim,Ji-Hoon Hwang,Min-Sun Kim,Sung Yoon Cho. (2023).Growth hormone treatment for children with mucopolysaccharidosis I or II. 대한의학유전학회지, 20 (2), 60-69

MLA

Minji Im,Chiwoo Kim,Juyoung Sung,Insung Kim,Ji-Hoon Hwang,Min-Sun Kim,Sung Yoon Cho. "Growth hormone treatment for children with mucopolysaccharidosis I or II." 대한의학유전학회지, 20.2(2023): 60-69

결제완료
e캐시 원 결제 계속 하시겠습니까?
교보 e캐시 간편 결제