학술논문
Osteoblastogenesis and osteolysis in the Zucker Diabetic Sprague Dawley rat humerus head
이용수 0
- 영문명
- Osteoblastogenesis and osteolysis in the Zucker Diabetic Sprague Dawley rat humerus head
- 발행기관
- 대한해부학회
- 저자명
- Gcwalisile Frances Dlamini Robert Ndou
- 간행물 정보
- 『Anatomy and Cell Biology』Vol.56(4), 552~561쪽, 전체 10쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2023.12.31
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.

국문 초록
영문 초록
The endocrinology of type 2 diabetes (T2D) and its predisposing factors have been studied extensively while its skeletal effects have received negligible research despite this being a global disease. The cellular and molecular association between proximal humeral fractures and T2D has not been fully elucidated. We aimed to study bone cell quantities and immunolabel osteogenic and antiosteogenic cytokines. The study used 12-week-old rats (23 males) consisting of 8 Sprague Dawley (SD) and 15 Zucker Diabetic Sprague Dawley (ZDSD). Weekly mass measurements were taken while fasting blood glucose levels were recorded every 2 weeks with oral glucose tolerance tests conducted once every 4 weeks. Upon termination at the age of 28 weeks, humeri were fixed in 10% buffered formalin, prior to decalcification in ethylenediaminetetraacetic acid. The bone samples were then processed in ascending grades of alcohol using an automatic processor before embedding in paraffin wax. Sections were cut at 5 μm thickness in a series for Haematoxylin and Eosin stain, and immunohistochemistry was performed with the anti-tartrate-resistant acid phosphatase (TRAP), anti-alkaline phosphatase (ALP), anti-bone morphogenetic protein 3 (BMP3), anti-transforming growth factor beta 1 (TGFβ1), anti-aged glycation end product (AGE) antibodies in the sequence. ZDSD rats had more adipocytes, BMP3 and AGEs expression with higher numbers of TRAP positive osteocytes and fewer ALP cells although no differences were found in TGFβ1 immunopositivity. We also found that T2D increases the number of AGEs immuno-positive cells, as well as its extracellular expression, thus providing a conducive environment for the interaction of the osteogenic cytokine and its antagonist to suppress osteoblastogenesis. ZDSD groups had higher adipocyte numbers therefore increased marrow adiposity in T2D.
목차
Introduction
Materials and Methods
Results
Discussion
ORCID
Author Contributions
Conflicts of Interest
Funding
Acknowledgements
References
해당간행물 수록 논문
- Morphological and morphometric study of pulmonary vein anatomy in relation to cardiac invasive and electrophysiological procedures
- Botulinum neurotoxin injection for treating plunged nose and post-rhinoplasty: anatomical perspectives of depressor septi nasi, nasalis, leveator labii superioris alaeque nasi muscle
- Rubus fruticosus leaf extract inhibits vascular dementia-induced memory impairment and neuronal loss by attenuating neuroinflammation
- Histology and immunohistochemistry of the human carotid sinus nerve
- A marginal branch of the left hepatic artery running along the umbilical vein and supplying the anterior surface of the liver left lobe: a report of 5 cases in 12 Japanese human fetuses
- Evaluating the effect of conditioned medium from mesenchymal stem cells on differentiation of rat spermatogonial stem cells
- The use of precontoured plates for midshaft clavicle fractures is not always the best course of treatment
- Dental characteristics on panoramic radiographs as parameters for non-invasive age estimation: a pilot study
- Morphological types and morphometrical measurements of the suprascapular notch in both dry bones and human cadavers: anatomical study to improve the outcomes of the diagnostic and interventional procedures in the shoulder region
- A clinical perspective on the anatomical study of digastric muscle
- Analyzing the factors that contribute to the development of embryological classical type of bladder exstrophy
- Anatomical variation of quadratus plantae in relation with flexor digitorum brevis
- A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats
- Variations of azygos vein: a cadaveric study with clinical relevance
- Magnetic resonance angiography in assessment of anomalies of anterior cerebral artery in adults
- Osteoblastogenesis and osteolysis in the Zucker Diabetic Sprague Dawley rat humerus head
- Effect of Sofosbuvir on rats’ ovaries and the possible protective role of vitamin E: biochemical and immunohistochemical study
- Fenestrated popliteal vein pierced by a branch of the tibial nerve
- Polymelia (thoracomelia), an extremely rare appearance of congenital anomalic limb in a Nepalese child and its embryological basis
- Azygos anterior cerebral artery associated with hypoplastic A1 fragment of right anterior cerebral artery
- Uncommon configuration of intercostobrachial nerves, lateral roots, and absent medial cutaneous nerve of arm in a cadaveric study
- The correlation of Septin4 gene expression with sperm quality, DNA damage, and oxidative stress level in infertile patients
- Trabeculae in the basilar venous plexus: anatomical and histological study with application to intravascular procedures
- Anatomical variations of the tibial nerve and their clinical correlation
참고문헌
관련논문
의약학 > 의학일반분야 BEST
더보기의약학 > 의학일반분야 NEW
- Development of a Standardized Clinical Practicum Model in Speech-Language Pathology: Analysis of Current Training Systems
- Household Characteristics Associated with the Presence of Stuttering
- 8 The Effect of Thermocouple and Flex Sensors in Real-Time Biofeedback System for Voice Training or Therapy
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!
