몬테카를로 방법을 이용한 치료용 방사성동위원소 사용 시 단일 세포에 대한 선량 분석

• 영문명: Analysis of Radiation Dose on Single Cells Using Therapeutic Radioisotopes Using the Monte Carlo Method
• 발행기관: 대한방사선과학회(구 대한방사선기술학회)
• 저자명: 김정훈(Jung-Hoon Kim) 김유수(Yu-Soo Kim)
• 간행물 정보: 『방사선기술과학』제45권 제5호, 433~438쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2022.10.31

영문 초록

Targeted radionuclides treatment (TRT) requires the establishment of treatment plans that consider various factors, such as the type of radionuclides, target organs, and administration methods. For this reason, in this study, the absorption dose of a single cell was analyzed according to the type of radioisotope used to treat target radionuclides. In this study, a simulation was performed on beta rays used in the treatment of target radionuclides at the cell level using MCNPX (ver. 2.5.0). First, according to the calculation formula, the beam path according to the type of radioisotope for treatment was calculated. Second, the amount of self-radiation by beta rays emitted from cell diameters of 5 μm and 10 μm cell nuclei was evaluated. As a result, it showed a high range proportional to the maximum energy of the beta-ray, and the highest self-dose distribution from 177 Lu radiation sources among therapeutic radioisotopes. This was analyzed as a result that is inversely proportional to the maximum energy of the beta-ray, and it suggests that the selection of a nuclide considering the range of the beta-ray is necessary in the treatment of target radionuclides in the future.

목차

Ⅰ. 서 론

Ⅱ. 대상 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

REFERENCES

키워드

표적 방사성 핵종 치료 몬테카를로 방법 방사성동위원소 자가선량 흡수선량 Targeted radionuclide therapy Monte carlo method Radioisotpe Self-radiation Absorbed dose