One-year Results of Aflibercept Treatment for Polypoidal Choroidal Vasculopathy with Good Visual Acuity

• 발행기관: 대한안과학회
• 저자명: 권지민(Ji Min Kwon) 박강윤(Kang Yeun Park) 이재정(Jae Jung Lee) 사공민(Min Sagong) 김현웅(Hyun Woong Kim)
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.35 No.1, 26~36쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.02.28

영문 초록

Purpose: To evaluate the one-year efficacy of intravitreal aflibercept injection in polypoidal choroidal vasculopathy (PCV)with best-corrected visual acuity (BCVA) of 20 / 40 or better. Methods: This was a multicenter retrospective study. The medical records of patients diagnosed with treatment-naïve PCVwere retrospectively reviewed. Patients with an initial BCVA of 20 / 40 or better and who had undergone intravitreal afliberceptinjection were included. Patients were treated with three consecutive monthly injections, followed by pro re nata regimenaccording to the clinician’s discretion at variable interval visits. The proportions of eyes for which BCVA was maintained(≤ 0.2 logarithm of the minimum angle of resolution change) or improved at 12 months were evaluated. The changes ofBCVA, central subfield macular thickness (CSMT), pigment epithelial detachment, and subretinal fluid also were assessed. Results: A total of 86 eyes were included. The mean number of injections for 12 months of treatment was 5.4 ± 1.7. BCVAwas maintained or improved in 94.2% (81 / 86) of cases. Mean BCVA (logarithm of the minimum angle of resolution)had changed from the baseline (0.23 ± 0.09) at 3 months (0.21 ± 0.14), 6 months (0.24 ± 0.22), and 12 months (0.20± 0.18), but with no statistical significance. CSMT had improved significantly from the baseline (336.1 ± 97.3 μm) at 3months (223.6 ± 47.22 μm), 6 months (239.6 ± 64.2 μm), and 12 months (223.8 ± 47.9 μm). Pigment epithelial detachmentwas observed in 93% of cases at the baseline, 72.1% at 3 months, and 69.8% at 12 months, showing a significantdecrease at all observation points. Subretinal fluid was observed in 91.9% of cases at the baseline, 20.9% at 3 months,and 29.1% at 12 months, showing a significant decrease at all observation points. Conclusions: In cases of PCV with good visual acuity, intravitreal aflibercept injections decreased CSMT and were effectivein maintaining visual acuity.

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Conflict of Interest

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키워드

Aflibercept Intravitreal injections Polypoidal choroidal vasculopathy