Enhancement of Melanin Synthesis by the Branch Extracts of Vaccinium oldhamii through Activating Tyrosinase Activity in B16F10 Melanoma Cells

• 발행기관: 한국자원식물학회
• 저자명: Kun Ho Son Jueng Kyu Baek Su Bin Park Ha Na Kim Gwang Hun Park Ho-Jun Son Hyun Ji Eo Jeong Ho Song Hyung Jin Jeong Jin Boo Jeong
• 간행물 정보: 『한국자원식물학회지』제31권 제5호, 547~553쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.10.30

영문 초록

This study was conducted to investigate the effect of branch extracts of Vaccinium oldhamii (VOB) on melanin synthesis in B16F10 cells. VOB promoted melanin production in absence or presence of α-melanocyte-stimulating hormone (α-MSH) in B16F10 cells. However, VOB did not affect the expression of tyrosinase and TRP-1 associated with melanin synthesis at the mRNA and protein levels in B16F10. But, VOB decreased TRP-2 protein level and induced tyrosinase activation in B16F10 cells. Inhibition of tyrosinase activity and tyrosinase knockdown attenuated VOB-mediated melanin synthesis. In conclusion, VOB may stimulate melanin synthesis through activating tyrosinase activity.

목차

Introduction

Materials and methods

Results and discussion

Acknowledgement

References

키워드

Melanin Melanogenesis Tyrosinase activity Vaccinium oldhamii