Intraoral HIV-associated Burkitt’s lymphoma: a rare case report with special emphasis on differential diagnosis

• 발행기관: 대한구강악안면외과학회
• 저자명: Mamata Kamat Uma Datar Sampada Kanitkar Sanjay Byakodi
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제45권 제4호, 225~229쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2019.08.30

영문 초록

Individuals with human immunodeficiency virus (HIV) infection present with unique intraoral manifestations of various neoplasms. Intraoral HIV-associated Burkitt’s lymphoma is a rare presentation, especially in patients of Indian origin and may present as an initial sign of HIV. The objective of this paper is to report a rare case of Burkitt’s lymphoma in an HIV-positive Indian patient along with a special emphasis on differential diagnosis. A 30-year-old Indian female presented with a solitary, well-defined, exophytic mass extending anteroposteriorly and buccolingually from the 35th to 38th regions with no evidence of intraosseous extension. An incisional biopsy was performed, and histopathology showed sheets of neoplastic lymphoid cells with numerous tingible body macrophages with clear cytoplasm, presenting a starry sky appearance, suggesting a diagnosis of BL. The tumor cells were positive for CD10, CD20, c-myc, and Epstein-Barr virus, with a nearly 100% Ki-67 proliferative index. The patient tested positive for HIV. This report indicates the importance of immunohistochemical analysis to differentiate Burkitt’s lymphoma from other similar lesions like diffuse large B-cell lymphoma. Thorough knowledge of the clinical presentation, etiopathogenesis, histopathology, and immunoprofile of intraoral HIV-associated Burkitt’s lymphoma is essential among clinicians and pathologists.

목차

Abstract

Ⅰ. Introduction

Ⅱ. Case Report

Ⅲ. Discussion

References

키워드

Aquired immunodeficiency syndrome Burkitt lymphoma Gingiva HIV Oral cavity