Prognostic value of nodal SUVₘₐₓ of ¹⁸F-FDG PET/CT in nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

• 발행기관: 대한방사선종양학회
• 저자명: So Jung Lee Chul Seoung Kay Yeon Sil Kim Seok Hyun Son Myung soo Kim Sea Won Lee Hye Jin Kang
• 간행물 정보: 『대한방사선종양학회지』제35권 제4호, 306~316쪽, 전체 11쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2017.12.30

영문 초록

Purpose: To investigate the predictive role of maximum standardized uptake value (SUVₘₐₓ) of 2-[¹⁸F]fluoro-2-deoxy-D-glucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) in nasopharyngeal cancer patients treated with intensitymodulated radiotherapy (IMRT). Materials and Methods: Between October 2006 and April 2016, 53 patients were treated with IMRT in two institutions and their PET/CT at the time of diagnosis was reviewed. The SUVₘₐₓ of their nasopharyngeal lesions and metastatic lymph nodes (LN) was recorded. IMRT was delivered using helical tomotherapy. All patients except for one were treated with concurrent chemoradiation therapy (CCRT). Correlations between SUVₘₐₓ and patients’ survival and recurrence were analyzed. Results: At a median follow-up time of 31.5 months (range, 3.4 to 98.7 months), the 3-year overall survival (OS) and disease-free survival (DFS) rates were 83.2% and 77.5%, respectively. In univariate analysis, patients with a higher nodal pre-treatment SUVₘₐₓ (≥ 13.4) demonstrated significantly lower 3-year OS (93.1% vs. 55.5%; p = 0.003), DFS (92.7% vs. 38.5%; p < 0.001), locoregional recurrence-free survival (100% vs. 50.5%; p < 0.001), and distant metastasis-free survival (100% vs. 69.2%; p = 0.004), respectively. In multivariate analysis, high pre-treatment nodal SUVₘₐₓ (≥ 13.4) was a negative prognostic factor for OS (hazard ratio [HR], 7.799; 95% confidence interval [CI], 1.506–40.397; p = 0.014) and DFS (HR, 9.392; 95% CI, 1.989–44.339; p = 0.005). Conclusions: High pre-treatment nodal SUVₘₐₓ was an independent prognosticator of survival and disease progression in nasopharyngeal carcinoma patients treated with IMRT in our cohort. Therefore, nodal SUVₘₐₓ may provide important information for identifying patients who require more aggressive treatment.

목차

Abstract

Introduction

Materials and Methods

Results

Discussion and Conclusion

Conflict of Interest

References

키워드

Nasopharyngeal carcinoma SUVₘ ₐ ₓ Prognostic factor