생약 복용에 따른 아플라톡신 B1의 인체모니터링 연구

• 영문명: Biomonitoring of Aflatoxin B1 Exposed by Herbal Medicine Intake
• 발행기관: 한국환경보건학회
• 저자명: 이진희(Jin Hee Lee) 류희영(Heui-Young Ryu) 김현경(Hyun-Kyung Kim) 김도정(Dojung Kim) 이영주(Young Joo Lee) 정수희(Su Hee Jung) 장동덕(Dong Deuk Jang) 김형수(Hyung Su Kim) 홍연표(Yeon-Pyo Hong) 윤혜성(Hae-Seong Yoon)
• 간행물 정보: 『한국환경보건학회지』제36권 제2호, 155~162쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2010.04.30

영문 초록

Aflatoxin B1, a known human carcinogen, is the member of aflatoxin subfamily that is most frequently found in contaminated foods. Epidemiological studies have suggested that aflatoxins may be associated with human liver cancer and acute hepatitis. Recently it was reported that the traditional medical herbs sold in domestic markets are contaminated with aflatoxins. Long-term administration of these contaminated medicines could result in adverse health effects. Therefore, it is important to evaluate the levels of exposure to aflatoxin in people who ingest traditional herbal medicines. Blood samples were collected, before and after the herbal medicine intake, from 151 subjects who visited the hospital. The metabolite of aflatoxin B1 in blood, aflatoxin B1-albumin (aflatoxin B1-lysine), is reportedly an appropriate internal exposure indicator, and its levels in the collected bloods were therefore analyzed using a liquid chromatography-mass spectrometry. The analytical method of aflatoxin B1-lysine in blood was firstly optimized in Korea and the levels were detected below quantification limits (2 pg/mg albumin) in this study population. Consequently, the exposure levels of aflatoxin B1 by ingestion of herbal medicines were low but it is important to monitor routinely due to the possibility of risk on the aflatoxin exposure.

키워드

aflatoxin B biomonitoring blood herbal medicine