키토산이 조골세포에 미치는 영향

• 영문명: EFFECTS OF CHITOSAN ON HUMAN OSTEOBLASTS
• 발행기관: 대한구강악안면외과학회
• 저자명: 김기홍(Ki-Hong Kim) 박영주(Young-Ju Park) 박준우(Jun-Woo Park) 이용찬(Yong-Chan Lee) 조병욱(Byoung-Ouck Cho) 안병근(Byoung-Keun Ahn)
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제28권 제4호, 280~285쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2002.08.30

영문 초록

As the result of the study concerning “bone inducibility of chitosan”, 1. “BMP-2”was observed mainly through the test when the “osteoblast”is exposed to the “chitosan”. The expression of BMP-2 was 542.63 times compared to control after 2 hours exposure and it was maintained 16.60 times till 24 hours. 2. The expression of BMP-4 was decreased compared to control during exposure. 3. The expression of BMP-7 revealed two peaks during exposure. 4. The expression of osteocalcin was increased in early phase, and then decreased. Although it is not clear whether the “chitosan”is clinically effective material as a “bone induction material”, we could say that it has a function for bone induction. Further detailed study will be required.

키워드

Osteoblast Chitosan BMP-2