Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review

• 영문명: Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review
• 발행기관: 대한구강악안면외과학회
• 저자명: Young-Hoon Kang June-Ho Byun Bong-Wook Park
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제40권 제5호, 240~245쪽, 전체 6쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2014.10.30

영문 초록

Angiokeratoma is a benign cutaneous lesion of the capillaries, presenting as dilated vessels in the upper part of the dermis. Although this disorder is classified into various types and has been occasionally reported in the skin of the scrotum or extremities, the involvement of the oral cavity mucosa has been rarely reported. The present study reports a case of angiokeratoma circumscriptum in the buccal mucosa. The expression of vascular endothelial growth factor (VEGF) and both of its receptors (VEGFR-1 and VEGFR-2) was demonstrated by immunohistochemistry in the endothelial cells lining the dilated vessels. The expression of VEGFR-2 was higher than that of VEGFR-1 in the endothelial cells in the lesion, indicating an increased rate of endothelial cell proliferation within the lesion. Interestingly, some of the endothelial cells co-expressed VEGF and its two receptors. These results suggest that endothelial cells in the pathologically dilated vessels possess VEGF autocrine growth activity involved in vasculogenesis and maintenance in angiokeratoma lesions. To our knowledge, this is the second report published on isolated oral angiokeratoma confined to the buccal mucosa and the first case report on angiokeratoma circumscriptum involving the buccal mucosa.

목차

I. Introduction

II. Case Report

III. Discussion

키워드

Angiokeratoma circumscriptum Buccal mucosa