생소한 위치에 발생한 기저양 편평세포암종

• 영문명: Basaloid Squamous Carcinoma of Unusual Sites
• 발행기관: 대한두경부종양학회
• 저자명: 조영미(Yong Mee Cho) 김규래(Kyu Rae Kim) 노재윤(Jae Y Ro) 장세진(Se J Jang) 김상윤(Sang Yoon Kim) 조경자(Kyung Ja Cho)
• 간행물 정보: 『대한두경부종양학회지』제20권 제2호, 189~193쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2004.11.30

영문 초록

Basaloid squamous carcinoma (BSC) is an uncommon aggressive variant of squamous cell carcinoma with a predilection for hypopharynx, tongue base, and larynx. We present 5 cases of BSC of unusual sites, each from maxillary sinus, external auditory canal, submandibular gland, tonsil, and nasopharynx. Only a few cases arising in these sites have been reported to date. Patients included 3 men and 2 women with the age range of 45-69 years (mean, 56.4 years). Microscopically, the tumors were characterized by solid lobules and nests of ovoid basaloid cells with abundant desmoplastic stroma. Comedonecrosis, peripheral palisading of tumor cells, trabecular pattern, and rosette-like arrangement were commonly observed. Tumor cells had scanty cytoplasm and their nuclei were ovoid, relatively uniform, and hyperchromatic. In two cases, concomitant squamous cell carcinoma in situ was identified. Immunohistochemical stains revealed that tumor cells were strongly positive for pancytokeratin and negative or weakly positive for p63. Being aware of BSC that can arise from unusual sites would help diagnose correctly and treat properly this rare and distinct clinicopathologic entity.

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키워드

기저양 편평세포암종 상악동 외이도 악하선 비인두 구개편도 Basaloid squamous carcinoma Maxillary sinus External auditory canal Submandibular gland Nasopharynx Tonsil