방사선 치료 중인 두경부 종양 환자를 대상으로 메게이스 내복 현탁액 경구투여 후 유효성 및 안전성에 관한 다기관, 공개, 관측연구

• 영문명: Multicenter, Open-Labeled, Observational Clinical Trial to Investigate the Efficacy and Safety of Oral Administration of Megace Suspension in Patients with Head and Neck Cancer During Radiotherapy
• 발행기관: 대한두경부종양학회
• 저자명: 김세헌(Se-Heon Kim) 김민식(Min Sik Kim) 김영모(Young Mo Kim) 김현수(Hyun Su Kim) 남순열(Soon Yuhl Nam) 노영수(Young Soo Rho) 박영학(Young Hak Park) 백정환(Chung Hwan Baek) 봉정표(Jung Pyo Bong) 이강대(Kang Dae Lee) 이용섭(Yong Seop Lee) 정광윤(Kwang Yoon Jung) 정성민(Sung Min Chung) 정필상(Phil Sang Chung) 주영훈(Young Hoon Joo) 주형로(Hyung Ro Chu) 최은창(Eun Chang Choi) 태경(Kyung Tae) 홍기환(Ki
• 간행물 정보: 『대한두경부종양학회지』제24권 제1호, 57~63쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2008.05.30

영문 초록

Background and Purpose ：Nausea, vomiting and weight loss are common problems that are encountered in the course of cancer patient treatment who are receiving radiotherapy. In this study, we are aiming to analyze the effect of megestrol acetate on quality of life of head and neck cancer patients receiving radiotherapy, resulting from improvement of weight loss, appetite and nutritional status via multicenter, open-labeled, observational clinical trial. Material and Methods ：A total of 270 patients from 10 medical institutes who are receiving radiotherapy or who have completed radiotherapy within 3 months, between February 2007 and February 2008, were selected as candidates for the study. Megestrol acetate suspension(megace) was given to the subjectives once a week for 4 weeks with the amount of 20ml(megestrol 800mg). Measurement of weight and questionnaire surveys were carried out three times: at the start of the study, 4 weeks after the start of the medication, and 4 weeks after the end of the medication, respectively. Results ：The group who has received megace had a total number of 199, and control group was 70. The group who have received megace showed mean weight loss of 1kg in 8 weeks, compared with the weight loss of 5.5kg in control group, which showed that the medication was effective in reducing the amount of weight loss(P=0.027). The group who received megace had a tendency to report a reduced rate of decrease in the score of appetite, nausea and vomiting, and QOL score, but it did not have statistical significance(P>0.05). Conclusion ：Megestrol acetate have reduced the degree of weight loss significantly, and it has a tendency to reduce the rate of decrease in appetite, aggravation of nausea and vomiting, and quality of life.

목차

서 론

대상 및 방법

결 과

고 찰

키워드

Megestrol acetate Head and neck cancer Radiotherapy Weight loss Anorexia 메게아스 두경부암 방사선 치료 체중감소 악엑질.