두경부의 점막연관 림프조직에서 발생한 림프절외 변연부 B세포 림프종의 임상 양상 및 치료 결과에 대한 고찰

• 영문명: Clinical Manifestation and Treatment Results of the Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Arising in the Head and Neck Region
• 발행기관: 대한두경부종양학회
• 저자명: 나윤찬(Yoon Chan Rah) 한규희(Kyu-Hee Han) 안수연(Soo-Youn An) 권택균(Tack-Kyun Kwon) 성명훈(Myung-Whun Sung) 김광현(Kwang Hyun Kim) 하정훈(J. Hun Hah)
• 간행물 정보: 『대한두경부종양학회지』제25권 제2호, 128~131쪽, 전체 4쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2009.11.30

영문 초록

Objectives ：Mucosa-associated lymphoid tissue(MALT) lymphoma of the head and neck region is relatively rare, but it has variable clinical and biological characteristics. Although there were few studies on this topic, there is still controversy regarding the best treatment. The authors retrospectively investigated the clinical courses and treatment results in 10 patients presenting with MALT-lymphoma in head and neck region except ocular adnexa. Material and Methods ：Ten patients with a histologically verified diagnosis of the extranodal mar-ginal zone B cell lymphoma arising in thyroid glands(3), larynx(3), oral cavity(2), oropharynx(1), salivary glands(1) were analyzed. Results ：Four patients were allocated to stage IE and another six patients to stage IIE according to the Ann Arbor staging system. Treatment consisted of local therapy(surgical resection and/or radiotherapy) in four patients and systemic chemotherapy with/without local therapy in six patients. Complete remission and partial remission were achieved in seven patients(70%) and two patients(20%), respectively. No recurrence or mortality was observed with a mean follow-up of 40.5 months. Conclusion ：Patients with MALT-lymphomas of the head and neck region were potentially treated by local modality in localized disease state. However systemic chemotherapy was also effective even in localized disease state and was well tolerated by pa-tients. And strict staging and close long-term monitoring were recommended considering its indolent progression.

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MALT lymphoma Extranodal marginal zone B-cell lymphoma Head and neck neoplasm 점막 연관성 림프조직 림프종 두경부 종양 치료.