Triflusal과 Ibudilast 동시처리에 의한 혈소판응집 및 혈액응고 억제효과

• 영문명: Inhibitory Effects on Platelet Aggregation and Blood Coagulation by Concurrent Administration of Trifusal and Ibudilast
• 발행기관: 대한약학회
• 저자명: 황인영(In Young Hwang) 손윤아(Yoon Ah Sohn) 황선아(Seon A Hwang) 구연경(Yean Kyoung Koo) 김선영(Sun Young Kim) 윤혜숙(Hye Sook Yun-Choi) 권순경(Soon Kyoung Kwon) 정춘식(Choon Sik Jeong)
• 간행물 정보: 『약학회지』제56권 제4호 (2012년), 248~253쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.31

영문 초록

This study aims to develop a novel regimen for enhanced efficacy and reduced side effect in inhibiting platelet aggregation and blood coagulation by concurrent administration of triflusal and ibudilast as anticoaggulants. The result shows this combination of triflusal and ibudilast (300~500 μM, respectively) has additive effect in inhibiting platelet aggregation and blood coagulation over the administration of truflusal or ibdilast as a single treatment. This pharmaceutical composition is expected to be useful for the prevention or treatment of various diseases and symptoms, for example, ischemic heart disease, ischemic cerebral infarction, arteriosclerosis, and thrombosis caused by the insertion of a stent.

키워드

triflusal ibudilast platelet aggregation blood coagulation