학술논문
Pharmacological Studies on Synthetic Cathepsin K Inhibitor, OST-1857 As Potential Treatment for Osteoporosis
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- 영문명
- 발행기관
- 대한약학회
- 저자명
- EJ Bae MK Kim MH Son HT Shin KJ Lim SH Kim WB Kim NC Kim YH Jung JH Lee HJ Hwang YA Shin SJ Lee CH Lee BY Lee JW Lee
- 간행물 정보
- 『정기총회 및 학술대회』제48회 정기총회 및 학술대회, 160~160쪽, 전체 1쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 1999.10.30
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- Chemical constituents of the root of Dipsacus asper
- Genetic assessment of atrazine in vitro in the Big Blue Rat2 lacl Transgenic cell line
- The Genetic Toxicity Study of YJA20379-8, a Reversible Proton Pump Inhibitor
- Absorption and pharmacokinetic disposition of itraconazole and hydroxyitraconazole
- Drug release from hydrogel nanoparticles composed of glycidyl methacrylate dextran conjugated with poly(ethylene glycol) macromer
- Simultaneous determination of YH439 and its metabolites M4, M5, M7 and M8 in dog plasma by high-performance liquid chromatography
- Terpyridine Derivatives： Potential Antitumor Agents
- Prescription Trends for Gastrointestinal Drugs in Patients without Digestive Symptoms
- THE ROLE OF NITRIC OXIDE IN GASTROINTESTINAL MOTILITY : LESSONS LEARNED FROM NITRIC OXIDE SYNTHASE GENE KNOCKOUT MICE
- Role of Glucose Utilization in the Restoration of Hypophysectomy-lnduced Rat Hepatic Cytochrome P450 2E1 by Growth Hormone
- Classification of Pharmaceuticals for process control using Near Infrared Spectroscopy and Soft Independence modeling of Class Analogies (SIMCA)
- Reversal of multidrug resistance by quinoline derivatives in cancer cells
- Mucosal AIDS Vaccine Development Using Recombinant Poliovirus Sabin 1 as a Live Vaccine Vector
- Modulation of Apoptosis and Cell Cycle in Human Cancer Cells by Novel Bile Acid Derivatives
- Process-Induced Effects on the Solid-State Stability of Pharmaceuticals
- HIV-1 Integrase Inhibitory Compounds from Korean Medicinal Plants
- Purification, characterization and cDNA cloning of melanin-inducing proteins by coleopteran insect, Tenebrio molitor larvae
- NEW IRIDOIDS FROM ASPERULA MAXIMOWICZII KOM
- Direct Activation Of Capsaicin Receptors By Products Of Lipoxygenases : Endogenous Capsaicin-Like Substances
- Isolation and characterization of a novel α-Glucosidase inhibitor from a Penicillium sp. F70614
- Annocherimolins A, B and C, three novel cytotoxic Annonaceous acetogenins from Annona cherimolia seeds
- Rheological properties of iota-, kappa- and lambda-carrageenans
- Induction of Differentiation and Apotosis by Hypericin in Human Promyelocytic Leukemia Cell Line HL-60
- Asymmetric Synthesis of (S)-4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)-1-butanol
- Synthesis and Antiviral Activity of Novel Apio Thiodideoxynucleosides
- A New Regioselective Synthetic Method for (E)-Enol ether
- Inhibitory effects of Bifidobacterium spp. on the growth of Helicobacter pylori
- Signal transduction mechanism via histamine receptor in cat duodenal smooth muscle cells
- Drug Design of Flavonoid Derivatives as Adenosine Receptor Antagonists
- Isoquinoline Alkaloids from the Bulbs of Crinum asiaticum var. japonicum
- Differentiatoin and apoptosis-inducing activities of isoflavones in HL60, human leukemia
- Synthesis of Isoxazole Analogs as Potential Therapeutic Agents for CNS Disorders
- Synthesis of Trans-Metanicotine Analogs
- Synthesis and Anti-HCMV Activity of Apio dideoxy didehydronucleosides
- Total Synthesis of a 6-demethylmansonone F
- Aflatoxin B1 Inhibits CD14-mediated Nitric Oxide Production in Murine Peritoneal Macrophages
- Influence of the Competitor on the Performance of the Haptenic Immunoassay
- Purification and Characterization of Heparin LyaseⅠfrom Bacteroides stercoris HJ-15, a Human Intestinal Bacterium
- Quinone reductase Induction of five species of Compositae extracts on HepG2 cells
- Ketoprofen Photosensitizes the Formation of Singlet Oxygen
- The factors that effect the freeze-drying rate and the stability of Salmonella typhi Ty21a
- Effects of nicotine and tobacco-specific nitrosamine on carcinogenesis
- Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz
- Two Noble heparin lyases from Bacteroides stercoris HJ-15, a human Intestinal Bacterium
- Development of a nail penetration model
- Evaluation of Neurotoxicity of Epoxidized soya bean oil (ESBO)
- In vivo pharmacokinetics study of antibody-endostatin fusion proteins for tumor cell-specific targeting
- Characterization of Components from Aerial part of Glechoma hederacea var. longituba
- Pyretic effect of Nitric Oxide and Carbon Monoxide
- Ergosterol Peroxide Derivatives from the Marine Sponge Spirastrella abata
- Antioxidative activity of Phellinus lintus
- Effects of Bombyx Mori Dried Feces(BMDF) on gene expression of glucose transporter and sucrase-isomaltase(SI) in sucrose force-feeding rats
- Brain distribution and acetylcholinesterase activities after the administration of dihydroevodiamine in rats
- Pharmacological Studies on Synthetic Cathepsin K Inhibitor, OST-1857 As Potential Treatment for Osteoporosis
- Effect of Carbon Clearance on Ethanol Treatment in Mice
- in vitro Evaluation of Generic Drugs
- Cell growth inhibition by a novel naphthoquione analog, as an inactivator of cdc25 phosphatse
- Effects of Diol Ginsenosides on the Production of Cytokines from T Helper Cells and Apoptosis of RINm5F Cells induced by Various Cytotoxic Chemicals
- Tribromo-dihydroxybenzyl methyl ether induces growth inhibition and apoptosis in MCF-7 human breast cancer cells
- PREPARATION AND EVALUATION OF PROSTAGLANDIN E1(PGE1) SUPPOSITORIES FOR ERECTILE DYSFUNCTION
- Modification of Cellular Response to Ionizing Radiation by Regulation of NF-kB
- A study on endocrine disruptors (Ⅱ) ： Estrogen receptor binding assay of phthalate analogues
- lontophoretic delivery of Ketoprofen using Acrylamide Hydrogel Patch
- Effects of Epoxidized Soy Bean Oil on Immune Functions in Mice
- Effects of Yukmijihwang-Tang on the Toxicity in Cadmium-poisoned rats (Ⅱ)
- Acute and Genetic Toxicities of Recombinant Anticoagulant Hirudine
- Activation of FcεRI inhibits the M2 pyruvate kinase through direct interaction with the FcεRI gamma chain
- Effects of Natural Product on the Xenobiotic Metabolizing Enzymes and Acetaminophen-Induced Hepatotoxicity
- Antigenotoxicity and Action mechanism of Quercetin and its Glycosides against Oxidative DNA Damage
- Optimal Synthesis Conditions of Hydrotalcite by Box-Wilson Experimental Design
- Apicidin and Its Derivatives as Histone Deacetylase Inhibitors Inhibit Angiogenesis
- Phytochemical constituents of Ainsliae acerifolia
- Distribution of 14C-labelled dehydroevodiamine in the rat
- Alteration of the Total Body Clearance of Propentofylline in Rats Treated with Caffeine
- Antiproliferative Effects of the Ethyl Acetate Soluble Fraction of Lonicerae flos in Tumor Cell Lines
- Cnicidine inhibits the degranulation of mast cells and the production of the nitric oxide in activated RAW 264.7 Cells
- The effect of temperature and pH on bromate ion formation by ozonation process
- Antioxidative Constituents from The Bark of Sorbus commixta Hedlund
- Several Diterpenes from Biota orientalis Leaves
- Cytotoxic compounds from Vitex rotundifolia on HL-60 and HepG2 cell lines
- Skin Permeation Characteristics of Lincomycin Preparations
- Cytotoxicity of taxanes isolated from Taxus cuspidate to human cancer cells in vitro
- Induction of cytochrome P450 1A and 2B by alpha - and beta-ionone in Sprague Dawley rats
- Immunotoxic effects of Bisphenol A after acute oral administration to mice
- Characterization of anti-inflammatory actions of Cimicifugae rhizoma
- The effects of tauroursodeoxycholic acid on the ischemia/reperfusion injury in isolated rat heart
- Reactive Oxygen Species Are Involved in the Induction of Apoptosis by yakuchinones in Hepatoma Cells
- Screening of Antimicrobial Activity against the Intestinal Bacteria from Traditional Medicinal Herbs and Prescriptions in Korea
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- Quantitative analysis of Phytoestrogen in Traditional Korean Foods and Medicinal Herbs
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- Novel Synthetic Method of Allyl Carbamates from Allyl Ethers Using Chlorosulfonyl Isocyanate
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- Studies on the Constituents of Impatiens textori(Ⅲ)
- Inhibitory Effects of Curcumin and Capsaicin on Phorbol Ester-Stimulated Activation of NF- kB and AP-1 Transcription Factors
- Molecular Discrimination of Antlers from Cervidae and Rangifer Species
- Characterization of Isomeric 1-Propargyl-2-(dimethoxymethyl)-1-cyclohexanols
- Synthesis of 2-Methyl-6-arylamino-4,7-dioxobenzothiazotes as Inhibitor of CDKs and Cytotoxic Agent
- DEVELOPMENT OF A COLON-SPECIFIC PRODRUG OF 5-FLUOROURACIL : SYNTHESIS AND PROPERTIES OF N-NICOTINYL-2-(5-FLUOROURACIL-1-YL)-D,L-GLYCINE
- Synthesis of Antiinflammatory Novel 7-Bromo 1,2-Benzothiazine derivatives
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- Effect of poloxamer 407 content on drug release from a multiparticulate pellet system
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- The Comparison of lenograstim and filgrastim on Autologous PBSCT Patients with High Dose Chemotherapy
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- Resolution of Terbutaline Enantiomers, Chiral Purity Test and Inclusion with Hydroxypropyl-β-cyclodextrin
- Pattern Recognition by Modified SIMCA Using Near-Infrared Spectra for the Identification of Geological Origins
- Formation of Fine Particles of Slightly Soluble Medicines by Planetary Ball Milling (2) ： Effect of Guest Species on Inclusion Compound Formation of Ursodeoxycholic Acid by Co-Grinding
- Suppression of immunoglobulin E-mediated anaphylactic reaction by Alpinia oxyphylla in Rats
- Pharmacokinetics of a New Proton Pump Inhibitor, YJA-20379-8, after Intravenous and Oral Administration to Spontaneously Hypertensive Rats and DOCA-salt-induced Hypertensive Rats
- Inhibitory Action of Thimerosal, a Sulfhydryl Oxidant, on Sodium Channels in Rat Dorsal Root Ganglion Neurons
- Up-regulations of NF-kB and AP-1 in CCI4 treated Rat Liver
- Purification and Chracterization of a New Thrombin-like Enzyme from Agkistrodon caliginosus (Korean Viper)
- PHARMACOKINETIC CHANGES OF A NEW PROTON PUMP INHIBITOR, YJA-20379-8, AFTER INTRAVENOUS AND ORAL ADMINISTRATION TO RATS WITH URANYL NITRATE-INDUCED ACUTE RENAL FAILURE
- Suppressive effects of simazine on immune response in mice
- Introducing carbamoyl phosphate synthetase I and ornithine transcarbamoylase gene into Chinese hamster ovary dhfr-cells : A decrease effect on the accumulation of ammonia in the cell culture media
- The effect of Kupffer cell on hypoxia/reoxygenation in isolated perfused rat liver
- The Crystal Structure of Phenyramidol Hydrochloride(C13H14N2O·HCI)
- Dual Activity of rhlL-4 on Human Mast cells Developed From Cord Blood and Fetal Liver Progenitor Cells Cultured with rhSCF
- Comparative Effects of Ca2+ Antagonists and Protein Kinase Inhibitors on Rat Aorta Contraction Induced by KCI and Phenylephrine
- Cytotoxic constituents from the roots of Anthriscus sylvestris
- Mechanism of cytochrome P450 1A1 induction by EA4, a quinolinedione, in mouse hepatoma cells
- Isolation and characterization of a cytotoxic substance having anticancer activity from soil Actinomycetes
- Isolation and Characterization of Chondroitin SuIfate from Bullfrog (Ranacatesbeiana)
- A Study on the Measurement for Potency of Serratiopeptidase in Tablet
- The Effect of Kupffer cell on hypoxia/reoxygenation in isolated perfused rat liver
- Characterization of Components from Eleutherococcus senticosus forma sachunense
- Reactive Oxygen Intermediates Generated by Intracellular Ca2+ Mediate Tamoxifen-induced Apoptosis in HepG2 Cells
- Inhibitory activity of 1,3-Bis-[4 -(β-D-glucopyranosyloxy)benzyl]citrate from Gastrodiae root on antigen-induced asthmatic responses in conscious guinea pigs
- DEVELOPMENT OF A COLON-SPECIFIC PRODRUG OF 5-FLUOROURACIL : SYNTHESIS AND PROPERTIES OF N-NICOTINYLGLYCYL-2-(5-FLUOROURACIL-1-YL)-D,L-GLYCINE
- PLASTIC MEMBRANE ELECTRODES FOR THE SELECTIVE DETERMINATION OF MEFENAMIC ACID
- Effect of Taurine on DSS-lnduced Chronic Colitis of Mice
- EFFECTS OF PHYSOSTIGMINE ON THE PHARMACOKINETICS OF PARATHION AND ITS METABOLITE AFTER INTRAVENOUS AND ORAL ADMINISTRATION OF PARATHION TO RATS
- Structure-Activity Relationship of Phenylpropanoids on Anti-inflammatory and analgesic activities
- 2-Conjugated alkenyl penam sulfones as b-lactamase inhibitors
- Inhibition of Cell Growth and Invasion by Allylthiopyridazine Derivatives in SK-Hep-1 Hepatocellular Carcinoma Cells
- Dose Uniformity Test of Acetaminophen Tablets combining with Near Infrared Spectrometry (NIRS) ; A new promising tool
- Activities of ketonic fraction from Leptospermum scoparium alone and in combination with other antibiotics, against various bacterial strains and fungi
- Size control of poly(lactide-co-glycolide) microspheres containing ovalbumin prepared by double emulsification method
- Pharmacokinetics of 4-Hydroxy-3-methoxy benzaldehyde, p-Hydroxybenzaldehyde and p-Hydroxybenzyl alcohol, Constituents of Gastrodia elata, in Rats
- Determination of aconitine and related alkaloids in processed Buza
- The role of p70s6k signaling pathway on the growth of the cancer cell
- Inhibition of dimethylnitrosamine-induced liver cirrhosis by synthetic choongWae compounds
- A New Monoclonal Antibody against Ochratoxin A
- DETERMINATION OF A NEW ASIATIC ACID DERIVATIVE, AS 2-006A, IN RAT PLASMA AND URINE, AND HUMAN PLSMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
- CONTRACTION INDUCED BY SPHINGOSYLPHOSPHORYLCHOLINE IN FELINE ILEAL SMOOTH MUSCLE CELLS
- ACTIVATION OF PROTEIN KINASE C BY PHORBOL DIBUTYRATE MODULATES GABA RECEPTOR BINDING IN RAT BRAIN SLICES
- Morphological changes of mouse jejunal villi by whole-body gamma irradiation
- Inhibitory effects of the aqueous extract of Astragalus menbranaceus on inducible nitric oxide synthesis in vitro
- Characterization of organic anion transport system at blood-brain barrier by internal carotid artery perfusion technique
- Effects of Foumulation variables on Model Antigen-Containing Biodegradable Microspheres for Sustained Release Vaccine Delivery
- Aldehyde dehydrogenase and glutathione
- Determination of doxylamine in postmortem blood and tissue
- Diarylheptanoids with in vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsuta
- HEPATIC AND INTESTINAL FIRST-PASS EFFECTS OF A NEW HEPATOPROTECTIVE AGENT, YH439, IN RATS
- Antioxidant Activity of Diarylheptanoids from the leaves of Alnus hirusta
- EXTREMELY LOW FREQUENCY MAGNETIC FIELD AND NOCICEPTION IN THE MICE ： INVOLVEMENT OF MELATONIN, OPIOID AND GABA RECEPTORS
- Inhibition of the production of nitric oxide from activated mouse macrophages by tanshinones from Salvia miltiorrhiza
- Evaluation of Dose Uniformity of Tablets Containing a Single Active Ingredient
- Preventive effects of maggot in CCI4-induced fibrosis of the liver
- Enantiomeric purity test of bevantolol by reversed-phase high performance liquid chromatography after derivatization with 2,3.4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate
- Establishment of Optimal Conditions on Single Cell Gel Electrophoresis (Comet Assay) with Mouse Lymphoma L5178Y Cells
- Preparation and characterization of PLGA microspheres containing salmon calcitonin
- Regulation of Cytokine Production by Exogenous Nitric Oxide
- Oompounds from the aerial part of Rumex aquatica (Ⅱ)
- Effects of KH-1 on neuroblastoma differentiation in vitro
- Design and Practical Synthesis of Optically Active Triazole Antifungals
- Synergistic Effects of Retinoic acid and Interferon Telomerase activity of humam breast cancer cell line
- Purification and Characterization of Inducible NO synthase in Staphylococcus aureus
- Simultaneous quantitative determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in human plasma by high-performance liquid chromatography
- Effect of quinolinedione derivatives, OQ1 and OQ21, on the expression of inducible cyclooxygenase and nitric oxide synthase in lipopolysaccharideactivated macrophages
- Effects of acharan sulfate on lipid metabolism in rats
- Carbon Tetrachloride Induces Multiple Canalicular Membrane Transport Alterations in Rat Liver
- Signaling mechanism for the TR8-inckJced NF-kB activation
- Development and evaluation of transdermal patch of clenbuterol
- The Flowers of Carthamus tinctorius : Potential Agent for Postmenopausal Disorder
- Activation of D3 dopamine receptor causes intracellular translocation of elongation factor 1γ Through Direct Interaction
- Direct interaction between D2 dopamine receptor and ret finger protein
- Mechanism of HCV Chronic Infection; Core as a Potential Antiviral Target
- Cytotoxicity of quinoline derivatives to luiman cancer cells in vitro
- In vitro interaction of the MBP-UreF fusion protein with the Klebsiella aerogenes urease apoenzyme
- Fine mapping of the UL47 transcript of human cytomegalovirus strain AD169
- Synthesis of New Monoterpenoid As Potential Antitumor Agents
- Development of new inexpensive and portable metal analyzer
- Chemical constituents of the root cortex of Robinia pseudo-acacia
- Diarylheptanoids from the barks of Alnus hirsuta var. sibirica
- Inhibitory Effect of Immediated Hypersensitivity by Alpiniae Fructus
- Development of in vitro environmental monitoring system by using immune cells
- The effect of Helicobacter pylori cytotoxin VacA on gastric epithelial cell growth and apoptosis
- The anti-proliferating effects of some plants on MCF-7 cell
- Identification of the cell growth regulators using a novel cell cycle protein Psp1 and a novel G-protein coupled receptor Stm1
- The Effect of Omeprazole-cholestyramine resinate and the Change in Signaling pathway on Reflux Esophagitis incduced Surgically in Rats
- Anti-inflammatory Activity of Sophoricoside from Sophora japonica
- Anti-atherogenic Effects of Cureumin in Hypercholesterolemic Rabbits
- Caspase-3-Mediated Cleavage of p21 WAF1/CIP1 Associated with Cyclin A/Cdk2 Complex Is a Mechanism of Cyclin A/Cdk2 Activation in Early Stage of Apoptosis of SK-HEP1 Cells
- RNA Helicase Activity of Hepatitis C Virus and Hepatitis G Virus NS3 Proteins
- Chiral Discrimination of Hydroxy car boxy lie Acids Diagnostic for Organic Acidurias by Achiral Dual-Capillary Column Gas Chromatography
- The Retinoblastoma Protein is Linked to the Activation of Ras
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